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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959118/
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure led to significant changes to efficacy in a cell-type dependent manner.Author: Joel Sunshine, Nupura Bhise, Jordan J. Green
https://www.ncbi.nlm.nih.gov/pubmed/19964958
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure led to significant changes to efficacy in a cell-type dependent manner.Author: Joel Sunshine, Nupura Bhise, Jordan J. Green
https://www.researchgate.net/publication/40451932_Degradable_Polymers_for_Gene_Delivery
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation ...
http://europepmc.org/articles/PMC3959118
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure led to significant changes to efficacy in a cell-type dependent manner.
https://www.mdpi.com/1420-3049/24/20/3744
Cationic polymers, such as polyethyleneimine are capable of condensing DNA to nanoparticles and facilitate gene delivery. Lack of biodegradation of polymeric gene delivery vehicles poses significant toxicity because of the accumulation of polymers in the tissue.Author: T. J. Thomas, Heidar-Ali Tajmir-Riahi, C. K. S. Pillai
https://www.academia.edu/15212622/Degradable_polymers_for_gene_delivery
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure led to significant changes
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · Another class of degradable polymers for gene delivery are the poly(β-amino esters) 174,175,176.Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079258/
Mar 01, 2011 · Bioreducible polymers, which possess mainly disulfide linkages in the polymer structures, have appeared as ideal gene delivery carriers due to the high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as decreased cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules …Author: Tae Il Kim, Sung Wan Kim, Sung Wan Kim
https://pubs.acs.org/doi/10.1021/acs.nanolett.8b02917
Previously, we demonstrated that poly (β-amino esters), a class of degradable polymers, are capable of systemic mRNA delivery to the lungs in mice when formulated into nanoparticles with poly (ethylene glycol)–lipid conjugates. Using experimental design, a statistical approach to optimization that reduces experimental burden,...Author: James C. Kaczmarek, Kevin J. Kauffman, Owen S. Fenton, Kaitlyn Sadtler, Asha K. Patel, Michael W. He...
https://pubs.rsc.org/en/content/articlelanding/2017/tb/c7tb00275k
Redox-sensitive disulfide based and hydrolytically degradable cationic polymers serve as gene carriers with excellent transfection efficiency and good biocompatibility owing to degradation in the cytoplasm. Additionally, biodegradable polymeric micelles with cell-targeting function are …Author: Ihsan Ullah, Khan Muhammad, Mary Akpanyung, Abdelilah Nejjari, Agnaldo Luis Neve, Jintang Guo, Yakai...
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