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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pulmonary-drug-delivery
Pulmonary drug delivery for lung cancer therapy has been only partly explored in recent decades even though it could represent an attractive alternative route of administration of drug-based therapies, including chemotherapy. Among the potential benefits, it can enhance the therapeutic ratio significantly by decreasing severe systemic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324823/
INTRODUCTION. Drug delivery to diseased organs, such as the lungs, is challenging, especially when the delivery of the therapeutic agent is limited or when there is an urgent need to insure high-density, location-specific distribution of the drug.Author: Arun Kumar, Mark Glaum, Nagwa El-Badri, Shyam Mohapatra, Edward Haller, Seungjoo Park, Leslie Patric...
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
ABOUT AUTHORS: Dr. N.V. Satheesh Madhav, Girish Dwivedi* Dehradun Institute of Technology, Faculty of Pharmacy Village Makkawala, Mussoorie Diversion Road, Dehradun-248009 *[email protected] ABSTRACT Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for site
https://www.atsjournals.org/doi/full/10.1513/pats.200409-049TA
Dec 01, 2004 · The lung is naturally permeable to all small-molecule drugs studied and to many therapeutic peptides and proteins. Absorption can be estimated using a simple animal test, intratracheal instillation. Inhalation offers a noninvasive route for the delivery of peptides and proteins that otherwise must be injected.Author: John S. Patton, C. Simone Fishburn, Jeffry G. Weers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59577/
Apr 12, 2001 · The patient inhales the drug within 10 s, during a slow and deep breath. ... suggested that pulmonary delivery of most therapeutic peptides and proteins is safe, at least after short-term use. In type 1 ... Microparticles used to improve systemic delivery of peptides and proteins via the lung may have a detrimental effect, although the ...Author: Remigius Uchenna Agu, Michael Ikechukwu Ugwoke, Michoel Armand, Renaat Kinget, Norbert Verbeke
https://www.researchgate.net/publication/232051208_Dry_powder_inhalation_systems_for_pulmonary_delivery_of_therapeutic_peptides_and_proteins
Methods: The scope of this review was defined by patent information on DPI devices, formulations and pulmonary delivery of therapeutic peptides and proteins for topical and systemic administration.
https://www.sciencedirect.com/science/article/pii/0168365994900817
This manuscript reviews the current sta- tus of the delivery of peptide and protein drugs by inhalation. Examples are included to demon- strate the usefulness of this approach for local as well systemic delivery of therapeutic peptides and proteins.Author: A. Adjei, P. Gupta
http://www.authorstream.com/Presentation/goutham.atla-872781-drug-delivery-to-lung-and-physiological-basis/
Mar 05, 2011 · Deep-lung delivery of therapeutic proteins:: 5-Mar-11 Drug Delivery To Lung 51 Deep-lung delivery of therapeutic proteins : Taking advantage of the body’s ability to transfer large molecules through the lungs is a better way to deliver drugs than sticking people with needles. Macromolecules, notably proteins and peptides, are large delicate ...
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