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https://www.researchgate.net/publication/38083628_Cladribine_Treatment_in_Two-Hour_Intravenous_Infusion_for_Previously-Treated_Low_Grade_B-Cell_Lymphoma_A_Pilot_Study
Cladribine at a dose of 0.09 mg/kg was administered in 2-hour intravenous infusion for 5 consecutive days. The treatment was repeated at a 28-day interval for at least 2 cycles, and its efficacy ...Estimated Reading Time: 6 mins
https://www.tandfonline.com/doi/abs/10.3109/10428199909145712
Jul 01, 2009 · (1999). Intermittent 2-Hour-Infusion of Cladribine as First-Line Therapy or in First Relapse of Progressive Advanced Low-Grade and Mantle Cell Lymphomas. Leukemia & Lymphoma: Vol. 35, No. 1-2…Cited by: 19
https://www.drugs.com/ppa/cladribine.html
Jul 11, 2020 · Mantle cell lymphoma (off-label use): IV: 5 mg/m 2 /day over 2 hours for 5 days every 4 weeks for 2 to 6 cycles (Inwards 2008) or 5 mg/m 2 /day over 2 hours for 5 days every 4 to 5 weeks for a maximum of 6 cycles (Rummel 1999) or 5 mg/m 2 /day over 2 hours for 5 days every 4 weeks for 2 to 6 cycles (in combination with rituximab) (Inwards 2008).Estimated Reading Time: 13 mins
https://chemocare.com/chemotherapy/drug-info/cladribine.aspx
· Cladribine is administered by infusion through a vein. The infusion may be over 1-2 hours on consecutive days, or may be a continuous infusion over several days. The way it is given depends on the protocol chosen by your physician. There is no pill form of cladribine.
https://clinicaltrials.gov/ct2/show/NCT02044796
Jan 24, 2014 · CONSOLIDATION CHEMOTHERAPY (G-CLA): Beginning within 6 weeks of achieving CR/CRp/CRi, patients receive G-CLA comprising filgrastim SC on days 0-5, cladribine IV over 2 hours daily on days 1-5, and cytarabine IV over 2 hours daily on days 1-5. Treatment continues for up to 4 courses in the absence of disease progression or unacceptable toxicity.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020229s034lbl.pdf
978±422 mL/h/kg and 4.5±2.8 L/kg, respectively. Cladribine plasma concentration after intravenous administration declines multi-exponentially with an average half-life of 6.7 +/- 2.5 hours. In general, the apparent volume of distribution of cladribine is approximately 9 L/kg, indicating an extensive distribution in body tissues.
https://ashpublications.org/blood/article/116/16/2884/27809/Beyond-hairy-cell-the-activity-of-cladribine-in
Patients received bolus cladribine at 0.14 mg/kg per day over 2 hours for 5 consecutive days every 28 days for up to 6 cycles, achieving an ORR of 98% (43 patients) and 32% CRs (14 patients). The median response duration was 1.3 years for partial responses and 3.1 years for CRs, ...
http://www.pdr.net/drug-summary/Cladribine-cladribine-3604
0.12 mg/kg/day IV on days 1, 2, and 3 repeated every 28 days for up to 6 cycles in combination with cyclophosphamide has been evaluated in 2 randomized, phase 3 trials.[43762] [50166] In 1 study, cladribine was administered over 30 minutes and the cyclophosphamide dosage was 250 mg/m2/day IV over 30 to 60 minutes on days 1, 2, and 3; therapy ...
https://www.eviq.org.au/haematology-and-bmt/leukaemias/hairy-cell-leukaemia/364-hairy-cell-leukaemia-cladribine
Notes: Various regimens for cladribine in hairy cell leukaemia have been reported: Continuous IV infusion of 0.1 mg /kg /day for seven days r r r r; IV infusion of 0.14 mg/kg /day over 2 hours for five days, r r IV infusion of 0.15 mg/kg over 2 hours weekly for six weeks r and; Subcutaneous bolus administration of 0.085 mg /kg /day for seven days r; The eviQ Reference committee believes that ...
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