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https://www.sciencedirect.com/science/article/pii/S0169409X98000556
The lack of available toxicological data will, more than anything else, limit the selection of CDs available for ophthalmic drug formulations. 4. Cyclodextrins and ocular drug delivery. In general, the ocular bioavailability of topically applied drugs is very low, frequently less than 5% 50, 51. The main ocular barrier to drug permeability into the eye consist of lipophilic membranes (i.e. cornea, conjunctiva and …Author: Thorsteinn Loftssona, Tomi Järvinen
https://www.sciencedirect.com/science/article/abs/pii/S0169409X98000556
Recent studies have shown that cyclodextrins are useful additives in ophthalmic formulations for increasing the aqueous solubility, aqueous stability and bioavailability of ophthalmic drugs, and to decrease drug irritation.Author: Thorsteinn Loftssona, Tomi Järvinen
https://www.ncbi.nlm.nih.gov/pubmed/16296758
Studies in both humans and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulation. However, the addition of cyclodextrins to existing formulations without further optimisation will seldom result in acceptable outcome.Author: Thorsteinn Loftsson, Pekka Jarho, Már Másson, Tomi Järvinen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750546/
Oct 14, 2005 · Cyclodextrins in drug delivery: An updated review Rajeswari Challa , Alka Ahuja , Javed Ali , and R. K. Khar Department of Pharmaceutics, Faculty of …Author: Rajeswari Challa, Alka Ahuja, Javed Ali, R. K. Khar
https://link.springer.com/chapter/10.1007/978-3-319-29346-2_12
Cyclodextrins in Ocular Drug Delivery. Abstract. Cyclodextrins are a group of water-insoluble, donut-shaped, naturally occurring cyclic oligosaccharides that are produced as a result of the bacterial breakdown of α-d-glucose polymers, such as cellulose. They are inactive molecules that do not display any innate biological activity.Author: Sridhar Anand, Vanildo Martins Lima Braga
https://link.springer.com/article/10.1208%2Fpt060243
Jun 01, 2005 · Cyclodextrins in drug delivery: An updated review. Abstract. The purpose of this review is to discuss and summarize some of the interesting findings and applications of cyclodextrins (CDs) and their derivatives in different areas of drug delivery, particularly in protein and peptide drug delivery and gene delivery.Author: Rajeswari Challa, Alka Ahuja, Javed Ali, R. K. Khar
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