We have collected information about Cyclodextrin-Containing Polymers For Gene Delivery for you. Follow the links to find out details on Cyclodextrin-Containing Polymers For Gene Delivery.
https://link.springer.com/article/10.1023/A:1023063117423
Dec 01, 2002 · The cyclodextrins endow the nucleic acid delivery vehicles with the ability to be modified by compounds that form inclusion complexes with the cyclodextrins, and these modifications can be performed without disruption of the polymer-nucleic acid interactions. Thus, cyclodextrin-containing polymers provide unique properties for gene delivery.Author: Mark E. Davis, Nathalie C. Bellocq
https://www.researchgate.net/publication/251251429_Cyclodextrin-Containing_Polymers_for_Gene_Delivery
A common property of all cyclodextrin-containing polymers for nucleic-acid delivery is that they are polycations.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307009/
Feb 02, 2012 · Structure of linear, cyclodextrin-based polymer (CDP) for small molecule delivery. The polymer consists of the cyclical sugar β-cyclodextrin that has been difunctionalized with the natural amino acid cysteine (CDDCys) and polyethylene glycol (PEG). ...Author: Jeremy D. Heidel, Thomas Schluep
https://www.researchgate.net/publication/300350240_Cyclodextrin-Containing_Polymers_for_Gene_Delivery
Modified polymer has found its application as a support material for gene delivery, cell culture, and tissue engineering.
https://www.mdpi.com/journal/polymers/special_issues/cd_containing_polymers
More recently, cyclodextrin-containing polymers have received a great deal of attention from researchers, as they are able to improve encapsulation properties, increase loading capacity, enhance the solubility and stability of hosted active molecules, etc. Soluble linear, branched and grafted cyclodextrin polymers are reported and insoluble cross linked one have also been reported.
https://pubs.acs.org/doi/10.1021/bc034125f
Transferrin is a well-studied ligand for tumor targeting due to upregulation of transferrin receptors in numerous cancer cell types. Here, we report the development of a transferrin-modified, cyclodextrin polymer-based gene delivery system.Author: Nathalie C. Bellocq, Suzie H. Pun, Gregory S. Jensen, Mark E. Davis
https://pubs.acs.org/doi/10.1021/bc0001084
Optimum transfection is achieved with the βCDP6 polymer. In vitro toxicity varied by 1 order of magnitude and the lowest toxicity is observed with βCDP8. The LD40 of the βCDP6 to mice is 200 mg/kg, making this polymer a promising agent for in vivo gene delivery applications.Author: Suzie J. Hwang, Nathalie C. Bellocq, Mark E. Davis
https://pubs.acs.org/doi/abs/10.1021/bc0001084
Optimum transfection is achieved with the βCDP6 polymer. In vitro toxicity varied by 1 order of magnitude and the lowest toxicity is observed with βCDP8. The LD40 of the βCDP6 to mice is 200 mg/kg, making this polymer a promising agent for in vivo gene delivery applications.Author: Suzie J. Hwang, Nathalie C. Bellocq, Mark E. Davis
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