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https://pubs.rsc.org/en/content/articlelanding/2011/cs/c0cs00019a#!
Cyclodextrin (CD) history has been largely dominated by their unique ability to form inclusion complexes with guests fitting in their hydrophobic cavity. Chemical funcionalization was soon recognized as a powerful mean for improving CD applications in a wide range of fields, including drug delivery, sensing
https://www.sciencedirect.com/science/article/pii/S0928493118309470
4. Cyclodextrin-based gene and drug co-delivery systems. Recently, gene and drug co-delivery systems have been developed rapidly due to its high therapeutic efficiency. Just as the name suggests, it can deliver chemotherapeutics and genetic drugs to target tissues synchronously [126,127]. In the course of cancer treatment, some tumor cells will ...Author: Dongjing Zhang, Pin Lv, Cheng Zhou, Yulin Zhao, Xiali Liao, Bo Yang
https://www.researchgate.net/publication/47645854_Cyclodextrin-Based_Gene_Delivery_Systems
While much of the initial success of gene delivery relied on viral vectors, non-viral vectors are emerging as promising gene delivery systems for efficacious treatment with decreased toxicity ...
https://link.springer.com/article/10.1007/s13346-020-00724-5
Feb 19, 2020 · Gene therapy is a powerful tool against genetic disorders and cancer, targeting the source of the disease rather than just treating the symptoms. While much of the initial success of gene delivery relied on viral vectors, non-viral vectors are emerging as promising gene delivery systems for efficacious treatment with decreased toxicity concerns.Author: Rebecca M. Haley, Riccardo Gottardi, Riccardo Gottardi, Robert Langer, Michael J. Mitchell
https://www.sciencedirect.com/science/article/pii/S0144861719314730
In this review, we summarize chemotherapy drugs for cancer treatment, classify various CD-based drug delivery systems, and describe their chemotherapy release and cancer treatment performance. In addition, current challenges and new opportunities for CD-based chemotherapeutic agents delivery systems are discussed.Author: Bingren Tian, Shiyao Hua, Jiayue Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885994/
There has been increasing interest recently to fabricate supramolecular systems for drug and gene delivery based on cyclodextrin materials. This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery.Author: Jianxiang Zhang, Peter X. Ma
https://pubs.acs.org/doi/full/10.1021/bm300936x
A cyclodextrin-based supramolecular hydrogel system with supramolecularly anchored active cationic copolymer/plasmid DNA (pDNA) polyplexes was studied as a sustained gene delivery carrier. A few biodegradable triblock copolymers of methoxy-poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly[2-(dimethylamino)ethyl methacrylate] (MPEG-PCL-PDMAEMA) with well-defined cationic block lengths …Author: Zibiao Li, Hui Yin, Zhongxing Zhang, Kerh Li Liu, Jun Li
https://www.researchgate.net/publication/272804576_ChemInform_Abstract_Cyclodextrin-Based_Gene_Delivery_Systems
Gene delivery is a process of introducing foreign DNA or RNA into host cells, which occurs in nature as horizontal gene transfer from one organism to another and is a mechanism of evolution [1,2].
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