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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574231/
Feb 15, 2013 · Cyclic peptides are a privileged and yet underexploited class of compounds for drug discovery. 1 Compared to their linear counterparts, cyclic peptides have reduced conformational freedom, which makes them more resistant to proteolysis and allows them to bind to their molecular targets with higher affinity and specificity. 2–4 They are widely produced in nature and exhibit a broad range of ...Author: Ziqing Qian, Tao Liu, Yu Yu Liu, Roger Briesewitz, Amy M. Barrios, Sissy M. Jhiang, Dehua Pei
https://www.hindawi.com/journals/jnm/2017/4562474/
2.1. Dipeptide. Recently, researchers have claimed that short peptides have the ability to self-assemble into many different nanostructures that can minimize the difficulty and cost of the fabrication process and simultaneously enhance the stability [35, 36].Among them, dipeptide self-assembled nanostructures are investigated intensively for various biomedical applications including drug delivery.Author: Taotao Fan, Xiaoyan Yu, Bing Shen, Leming Sun
http://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1085&context=oa_diss
cyclic peptides: design, characterization, self-assembly, and applications as nano drug delivery systems by amir nasrolahi shirazi a dissertation submitted in partial fulfillment of the requirements for the degree of doctor of philosophy in pharmaceutical sciences university of rhode island 2013
https://www.researchgate.net/publication/51635345_Cell-Penetrating_Homochiral_Cyclic_Peptides_as_Nuclear-Targeting_Molecular_Transporters
Cyclic cell-penetrating peptides are relatively a newer class of peptides that have a huge potential for the intracellular delivery of therapeutic agents aimed at treating challenging ailments ...
https://research.cbc.osu.edu/pei.3/research/chemical-biology/
Previous cell-penetrating peptides (CPPs) generally have low cytosolic delivery efficiencies, because of inefficient endosomal escape. In this study, a family of small, amphipathic cyclic peptides was found to be highly efficient CPPs, with cytosolic delivery efficiencies of up to 120% (compared to 2.0% for Tat).
https://www.sciencedirect.com/science/article/pii/S1525001617305208
To identify peptides that enhance the delivery of AONs to skeletal and cardiac muscle, we used the Ph.D.-C7C phage display peptide library. A schematic outline of the screening procedure is given in Figure 1.We performed a first-round in vitro screening using human control myotubes in which internalized and surface-bound phages were isolated and amplified.Author: Silvana M.G. Jirka, Peter A.C. ’t Hoen, Valeriano Diaz Parillas, Christa L. Tanganyika-de Winter, Ru...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075989/
Jun 24, 2014 · Intracellular Delivery of Cyclic Peptides. In recent years, there has been much interest in cyclic peptides as therapeutic agents and biomedical research tools. 69,70 For example, cyclic peptides are effective for inhibition of protein–protein interactions, 47,71−73 which are challengingAuthor: Ziqing Qian, Jonathan R. LaRochelle, Bisheng Jiang, Wenlong Lian, Ryan L. Hard, Nicholas G. Selner, ...
https://ui.adsabs.harvard.edu/abs/2014PhDT.......402S/abstract
Parang's laboratory has reported that Amphiphilic Cyclic Peptides (ACPs) containing positively charged arginine and hydrophobic tryptophan residues as potential candidates for drug delivery. Cyclic peptides have several benefits compared to linear peptides, such as rigidness of structure and stability against proteolytic enzymes.Author: Naser Ali Sayeh
https://pubs.acs.org/doi/10.1021/cb3005275
Cyclic peptides hold great potential as therapeutic agents and research tools, but their broad application has been limited by poor membrane permeability. Here, we report a potentially general approach for intracellular delivery of cyclic peptides. Short peptide motifs rich in arginine and hydrophobic residues (e.g., FΦRRRR, where Φ is l-2-naphthylalanine), when embedded into small- to ...Author: Ziqing Qian, Tao Liu, Yu Yu Liu, Roger Briesewitz, Amy M. Barrios, Sissy M. Jhiang, Dehua Pei
http://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1231&context=oa_diss
amphiphilic cyclic cell-penetrating peptides as drug delivery vehicles and antimicrobial peptides by donghoon oh a dissertation submitted in partial fulfillment of the requirements for the degree of doctor of philosophy in biomedical and pharmaceutical sciences university of rhode island 2014
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