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https://www.sciencedirect.com/science/article/pii/S1359644616000209
However, cubosomes, owing to some unique advantages, seem to be promising oral delivery vehicles for poorly water-soluble actives. First of all, as a result of being lyotropic, cubosomes encapsulate poorly water-soluble drugs in the lipid bilayer part of their structure in a solubilized form, avoiding the drug precipitation in the GI tract.Author: Zahra Karami, Mehrdad Hamidi
https://www.onlinelibrary.wiley.com/doi/full/10.1002/anie.201804067
Jun 21, 2018 · This is not ideal for delivery vehicles and it was therefore suggested that chemical modification to the lipids or stabilizers are needed to alter the release profile. 111 Since then Cinnarizine, a poorly water‐soluble drug, has been released in a controlled manner from phytantriol cubosomes via oral administration in a rat model.Author: Hanna M. G. Barriga, Margaret N. Holme, Molly M. Stevens, Molly M. Stevens
https://www.researchgate.net/publication/230075805_Cubosomes_as_Delivery_Vehicles
Cubosomes as Delivery Vehicles. ... As a result, cubosomes could not be obtained and vesicles were formed instead, presumably due to the existence of F127, which gave a positive curvature to the ...
https://www.researchgate.net/publication/328649787_A_review_on_cubosome_The_novel_drug_delivery_system
Cubosomes are the biocompatible novel approach for the drug delivery system. The controlled release application of these nanoparticles is of a great significance in cosmeceutical and ...
http://ijpsr.com/bft-article/cubic-liquid-crystalline-nanoparticles-cubosomes-a-novel-carrier-for-drug-delivery/?view=fulltext
Formulation with cubosomes has shown some advantages: They prove to improve the absorption, serve as delivery vehicles for poorly water-soluble drugs, bioadhesive and lipid-based nanoparticles they are biocompatible with the biological environment. Bicontinuous structure makes it possible to incorporate hydrophilic, hydrophobic or amphiphilic ...
https://www.ncbi.nlm.nih.gov/pubmed/25745885
Cubosomes and other potential ocular drug delivery vehicles for macromolecular therapeutics. ... therapeutics to the posterior segment of the eye and defines the key requirements placed on particulate drug delivery vehicles (DDVs) to be suitable for this application. Recent developments in macromolecular drug delivery to treat this disease as ...Author: Terence E Hartnett, Andrea J O’Connor, Katharina Ladewig
https://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc05842j#!
Lipidated polymers, like their protein counterparts, may be useful in fields as diverse as biochemistry and drug delivery. As such, strategies for preparing lipidated polymers with defined molecular architecture are clearly warranted. Herein, we describe a broadly-applicable methodology for synthesizing such
https://www.slideshare.net/ShrikantDivekar/cubosomes-a-drug-delivery-system-by-shree-final-okkkkkkkk-140662050
Apr 13, 2019 · Cubosomes a drug delivery system Introduction : • Cubosomes are the square and rounded particles with internal cubic lattices visible. • Cubosomes are self-assembled nanostructured particles formed by aqueous lipid and surfactant systems.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007820/
To develop a novel vehicle based on cubosomes as an ophthalmic drug delivery system for flurbiprofen (FB) to reduce ocular irritancy and improve bioavailability.FB-loaded cubosomes were prepared using hot and high-pressure homogenization. Cubosomes were ...Author: Shun Han, Jin-qiu Shen, Yong Gan, Hai-ming Geng, Xin-xin Zhang, Chun-liu Zhu, Li Gan
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