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https://www.ncbi.nlm.nih.gov/pubmed/27020469
AREAS COVERED: Drug distribution into the CSF is a function of drug transport across the choroid plexus, which forms the blood-CSF barrier, and not drug transport across the BBB, which is situated at the microvascular endothelium of brain. Drug injected into CSF undergoes rapid efflux to the blood compartment via bulk flow.Author: William M. Pardridge
https://www.sciencedirect.com/science/article/pii/S0169409X20300120
Administration of substances directly into the cerebrospinal fluid (CSF) that surrounds the brain and spinal cord is one approach that can circumvent the blood-brain barrier to enable drug delivery to the central nervous system (CNS).Author: M.J. Fowler, J.D. Cotter, B.E. Knight, E.M. Sevick-Muraca, D.I. Sandberg, D.I. Sandberg, R.W. Sirian...
https://www.tandfonline.com/doi/full/10.1517/17425247.2016.1171315
Sep 07, 2016 · ABSTRACTIntroduction: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago. Misconception 1 is that drug distribution into CSF is a measure of BBB transport. Misconception 2 is that drug injected into the CSF compartment distributes …Author: William M. Pardridge
https://www.researchgate.net/publication/299492074_CSF_blood-brain_barrier_and_brain_drug_delivery
Introduction: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a barrier between blood ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421134/
Folate transport and exosome release into the CSF, plasma protein transport, and various receptor-mediated endocytosis pathways may prove useful mechanisms to exploit for efficient drug delivery into the CSF. This calls for a clear evaluation of transcytosis mechanisms at the blood-CSF barrier, and a thorough evaluation of CSF drug delivery rates.Author: Nathalie Strazielle, Jean-François Ghersi-Egea
https://www.tandfonline.com/doi/abs/10.1517/17425247.2016.1171315
Sep 07, 2016 · Introduction: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago.Misconception 1 is that drug distribution into CSF is a measure of BBB transport. Misconception 2 is that drug injected into the CSF compartment distributes to the inner ...Author: William M. Pardridge
https://www.sciencedirect.com/science/article/pii/S0887899416302806
Intrathecal delivery methods have been used for many decades to treat a broad range of central nervous system disorders. A literature review demonstrated that intracerebroventricular route is an established and well-tolerated method for prolonged central nervous system drug delivery in …Author: Jessica L. Cohen-Pfeffer, Sridharan Gururangan, Thomas Lester, Daniel A. Lim, Adam J. Shaywitz, Manf...
https://www.researchgate.net/profile/William_Pardridge/publication/299492074_CSF_blood-brain_barrier_and_brain_drug_delivery/links/574a230208ae2e0dd30188eb/CSF-blood-brain-barrier-and-brain-drug-delivery.pdf
(BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago. Misconception 1 is that drug distribution into CSF is a measure of BBB ...
https://www.kcl.ac.uk/study/postgraduate/research-groups/drug-delivery
The Drug Delivery Group comprises Dr Ben Forbes, Professor Gino Martini, Dr Khuloud Al-Jamal, Dr David Begley, Dr Ken Bruce, Dr Lea Ann Dailey, Dr Paul Royall, Dr Stuart Jones, Dr Sarah Thomas and Emeritus Professor Gary Martin. The Group undertakes research and development in pharmaceutical ...
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · Research on the blood–brain barrier (BBB) has led to the concept of a complex, dynamic interface between the central nervous system (CNS) and periphery. Banks considers how this new ...Author: William A. Banks
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