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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657605/
Convection-enhanced delivery to brain parenchyma Accessibility of pharmacological agents from the bloodstream to the CNS meets with a formidable obstacle in the form of the BBB [ 1 ]. There is an absence of direct intracranial administration-only agents that are actively transported through the BBB or that are otherwise permeable through the barrier, which can directly kill tumor cells.Author: Waldemar Debinski, Stephen B Tatter
https://braintumorcenter.ucsf.edu/treatment/experimental-diagnostics-therapies/convection-enhanced-delivery
Convection Enhanced Delivery. Using standard chemotherapy on brain tumors is challenging, considering that many of these drugs (administered as a pill, or injected intravenously) do not enter the brain easily. Increasing dosages would not work either, since these medications would reach toxic concentrations in the body before reaching effective...
https://www.ncbi.nlm.nih.gov/pubmed/19831841
Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment. Drugs are delivered through one to several catheters placed stereotactically directly within the tumor mass or around the tumor or the resection cavity.Author: Waldemar Debinski, Stephen B Tatter
https://www.mayo.edu/research/labs/experimental-drug-therapeutics-pediatric-brain-tumor/research-activities/convection-enhanced-delivery-overcoming-bottleneck-brain-drug-development
Convection-Enhanced Delivery — Overcoming the Bottleneck in Brain Drug Development. Malignant midbrain tumors, including diffuse intrinsic pontine gliomas (DIPGs), are among the most lethal cancers in younger populations. The presence of the blood-brain barrier (BBB) often leads to failure of conventional systemic drug delivery for cerebral diseases.
https://www.medscape.com/viewarticle/712531
Nov 06, 2019 · The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment.
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