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https://www.sciencedirect.com/science/article/pii/S0168365919305863
The transdermal route has been popular for cosmetic and other local therapeutic applications for thousands of years. To date >20 low molecular weight (≤400 Da) drugs have been approved by the US Food and Drug Administration for transdermal drug delivery , contributing toAuthor: Parbeen Singh, Andrew Carrier, Yongli Chen, Sujing Lin, Jinlin Wang, Shufen Cui, Xu Zhang
https://www.researchgate.net/publication/336682946_Polymeric_microneedles_for_controlled_transdermal_drug_delivery
Polymeric microneedle (MN) systems are interesting transdermal drug delivery systems because of their controlled drug delivery, tunable properties, and ease of patient self-administration.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs.Author: Mark R Prausnitz, Robert Langer
https://www.sciencedirect.com/science/article/pii/S0169409X17301801
Transdermal drug delivery is a prospective drug delivery strategy to complement the limitations of conventional drug delivery systems including oral and injectable methods. This delivery route allows both convenient and painless drug delivery and a sustained release profile with reduced side effects.Author: Hyunjae Lee, Changyeong Song, Seungmin Baik, Dokyoon Kim, Taeghwan Hyeon, Dae-Hyeong Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
Sep 28, 2014 · The controlled drug delivery technology has progressed over the last six decades. It began in 1952 with the introduction of the first sustained release formulation. The 1st generation (1950-1980) of drug delivery was focused on developing oral and transdermal sustained release systems and establishing the controlled drug release mechanisms.Author: Kinam Park
https://www.researchgate.net/publication/326835433_Iontophoresis_Controlled_transdermal_drug_delivery_system
is an complete overview of the controlled transdermal drug delivery . of ions/proteins/peptides b y iontophoresis as well as the principles, laws, mechanisms, factors, ...
https://academic.oup.com/bjaed/article/7/5/171/535087
Oct 01, 2007 · Transdermal delivery systems. There are two designs of transdermal patch currently available: the reservoir, or membrane-controlled system, and the matrix system. A reservoir patch holds the drug in a gel or solution and delivery is determined by a rate-controlling membrane between the drug reservoir and the skin (Fig. 3).Author: Lyn Margetts, Richard Sawyer
https://www.ondrugdelivery.com/skin-mountable-flexible-needle-patch-for-minimally-invasive-controlled-drug-delivery/
Citation: Lee CH, Lee EK, “Skin-Mountable Flexible Needle Patch for Minimally Invasive Controlled Drug Delivery. ONdrugDelivery Magazine, Issue 97 (May 2019), pp 22-25. Chi Hwan Lee and Eun Kwang Lee introduce a skin-mountable flexible needle patch and discuss its …
https://www.mddionline.com/polymers-controlled-drug-delivery
For transdermal drug delivery, the penetration of the drug through the skin constitutes an additional series of diffusional and active transport steps, as shown schematically in Figure 4. 2 (A thorough analysis of transdermal drug delivery may be found in a review by Cleary 3 or in other sources listed in the bibliography.) Figure 4.
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