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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898614/
In such systems, the drug release is primarily controlled by the relative partitioning of solubilized drugs between the hydrogel and the release medium, and is independent of the mesh size of the hydrogel …Author: Jianyu Li, David J. Mooney
https://www.sciencedirect.com/science/article/pii/S1359644602022559
Hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogels also show stimuli-responsive changes in their structural network and hence, the drug release.Author: Piyush Gupta, Kavita Vermani, Sanjay Garg
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384686/
Feb 08, 2019 · Diffusion-controlled drug delivery with hydrogels uses reservoir or matrix devices that allow diffusion-based drug release through a hydrogel mesh or pores filled with water. In the reservoir delivery system, the hydrogel membrane is coated on a drug-containing core producing capsules, spheres or slabs that have a high drug concentration in the very center of the system to facilitate a constant drug-release rate.Author: Radhika Narayanaswamy, Vladimir P. Torchilin
https://www.nature.com/articles/natrevmats201671
Oct 18, 2016 · Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release …Author: Jianyu Li, David J. Mooney
http://csip.cornell.edu/Curriculum_Resources/CSIP/Neeves/KNeeves_studentversion.pdf
Controlled Release Drug Delivery from Hydrogels Student’s Guide Keith Neeves CSIP Graduate Fellow Cornell University 1 Objective The aim of this project will be to design a drug delivery system capable of delivering a drug over an extended period of time at a known rate to a local area. The method of using implantable materials to treat tissuesFile Size: 315KB
https://pubs.acs.org/doi/10.1021/bm901235g
Jan 22, 2010 · Tethering drug substances to a gel network is an effective way of controlling the release kinetics of hydrogel-based drug delivery systems. Here, we report on in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins.Author: Ferdinand Brandl, Nadine Hammer, Torsten Blunk, Joerg Tessmar, Achim Goepferich
https://www.intechopen.com/books/smart-drug-delivery-system/swellable-hydrogel-based-systems-for-controlled-drug-delivery
The controlled delivery of drugs can be effectively obtained using systems based on hydrogels. Tablets, to be orally administered, represent the simplest and the most traditional dosage systems based on hydrogel.Author: Diego Caccavo, Sara Cascone, Gaetano Lamberti, Anna Angela Barba, Anette Larsson
https://pubs.acs.org/doi/abs/10.1021/ed300286v
A laboratory experiment on controlled-release drug delivery systems is presented. The intended audience is high school chemistry and biology students. The exercise is meant to complement curriculum on diffusion, enzyme reactions, and polymerization. In the experiment, students used a gelatin hydrogel as the drug delivery system and food dye as a drug. Bromelain, a protease found in pineapples ...Author: Joanna L. Sylman, Keith B. Neeves
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Hydrogels are efficient candidates for controlled release, bioadhesive and/or targeted drug delivery as they can encapsulate biomacromolecules, including proteins and DNA, and hydrophilic …Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
https://www.sciencedirect.com/science/article/pii/S0032386108000487
“Plum pudding”, composite hydrogels containing drug encapsulated in a secondary controlled release vehicle (e.g. microparticles, nanoparticles, microgels, liposomes, micelles). D 1 and D 2 represent the diffusion coefficients of drug out of the hydrogel (D 1 = release from secondary release vehicle; D 2 = diffusion through hydrogel).Author: Todd R. Hoare, Daniel S. Kohane
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