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https://link.springer.com/article/10.1023%2FA%3A1014870102295
Aug 01, 1999 · The chemical and biological integrity of released DNA was not changed. Conclusions. These low cost, and adjustable, controlled DNA delivery systems, using FDA-approved biocompatible/biodegradable and implantable/injectable materials, could be useful for in vivo gene delivery, such as DNA vaccination and gene therapy.Author: Dan Luo, Kim Woodrow-Mumford, Nadya Belcheva, W. Mark Saltzman
https://www.sciencedirect.com/science/article/pii/S1525001604001236
Controlled release systems typically employ polymeric biomaterials that deliver vectors according to two general mechanisms: (i) polymeric release, in which the DNA is released from the polymer, or (ii) substrate-mediated delivery, in which DNA is retained at the surface.Author: Angela K. Pannier, Lonnie D. Shea
https://www.deepdyve.com/lp/springer-journals/controlled-dna-delivery-systems-zo3wQSRKRY
Oct 19, 2004 · Controlled DNA Delivery Systems Genes are of increasing interest as pharmaceuticals, but current methods for long-term gene delivery are inadequate. Controlled release systems using biocompatible and/or biodegradable polymers offer many advantages over …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
Sep 28, 2014 · The controlled drug delivery technology has progressed over the last six decades. It began in 1952 with the introduction of the first sustained release formulation. The 1st generation (1950-1980) of drug delivery was focused on developing oral and transdermal sustained release systems and establishing the controlled drug release mechanisms.Author: Kinam Park
https://nebraska.pure.elsevier.com/en/publications/controlled-release-systems-for-dna-delivery
Adapting controlled release technologies to the delivery of DNA has the potential to overcome extracellular barriers that limit gene therapy. Controlled release systems can enhance gene delivery and increase the extent and duration of transgene expression relative to more traditional delivery methods (e.g., injection).Author: Angela K. Pannier, Lonnie D. Shea
https://www.researchgate.net/publication/8474665_Controlled_Release_Systems_for_DNA_Delivery
Controlled release systems can enhance gene delivery and increase the extent and duration of transgene expression relative to more traditional delivery methods (e.g., injection).
https://www.researchgate.net/publication/313575700_Controlled_Gene_Delivery_Systems_for_Articular_Cartilage_Repair
Controlled Gene Delivery Systems for Articular Cartilage Repair 263 in the last few years by identifying novel methods and factors that may stimulate the reparative processes in sites of cartilage ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425417/
Nov 07, 2014 · Oxidoreductases have been widely exploited to serve as a promising target for drug delivery systems or biosensing due to their fundamental role in oxidative environments which are generated by many diseases including diabetes and cancer. 57, 58 For example, glucose oxidase (GOx) is extensively utilized as a gate in responsive, controlled release systems or a diagnostic tool in the …Author: Quanyin Hu, Prateek S. Katti, Zhen Gu
https://www.sciencedirect.com/science/article/pii/S0378517313010351
The principle of physical gene delivery systems is to use mechanical, ultrasonic, electric, hydrodynamic or laser-based energy in order to create temporary weak points in the membrane of the target cell, by causing transient injuries or defects in it and allows the DNA to inter the cell by diffusion.Author: D. Ibraheem, A. Elaissari, H. Fessi
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Hydrogels are efficient candidates for controlled release, bioadhesive and/or targeted drug delivery as they can encapsulate biomacromolecules, including proteins and DNA, and hydrophilic or hydrophobic drugs 110. Hydrogel-based drug delivery systems can be used in different ways for oral, rectal, ocular, epidermal,...Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
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