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https://www.sciencedirect.com/science/article/pii/S0168365903001949
Thus, interest in biodegradable polymers developed for two reasons; firstly, surgical removal of drug-depleted delivery systems of non-biodegradable polymers is difficult and non-removal may pose toxicological problems; secondly, diffusion-controlled delivery systems, although excellent means of achieving predetermined rates of drug delivery ...Author: V.R. Sinha, Aman Trehan
https://www.sciencedirect.com/science/article/pii/S0939641197000568
These results show the necessity of further investigation of the mechanisms and factors which control the release of proteins from PLGA-based systems. Taking into account this information, the primary goal of this work has been to create PLGA nanospheres with an important capacity for the association and controlled release of proteins.Author: M.D Blanco, M.J Alonso
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347861/
Sep 01, 2011 · In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications.PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer.Author: Hirenkumar K. Makadia, Steven J. Siegel
https://www.researchgate.net/publication/232079116_Use_of_Surfactants_in_Polylactic_Acid_Protein_Microspheres
Use of Surfactants in Polylactic Acid Protein Microspheres Article in Drug Development and Industrial Pharmacy 21(5):549-558 · October 2008 with 65 Reads How we measure 'reads'
https://www.researchgate.net/publication/248280460_Controlled_release_of_bovine_serum_albumin_from_hydroxyapatite_microspheres_for_protein_delivery_system
Controlled release of bovine serum albumin from hydroxyapatite microspheres for protein delivery system Article in Materials Science and Engineering B 148(1):162-165 · February 2008 with 41 Reads
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627499/
APPROACHES FOR MUCOSAL DELIVERY OF THERAPUTIC PROTEINS. Besides parenteral delivery, which is the most widely followed route for delivery of proteins, considerable emphasis has gone into exploring non-injectable methods of protein delivery including oral, 41 rectal, 42 buccal, 43 transdermal, 44 nasal, 45 and ocular 46 routes.Author: Rajesh Singh, Shailesh Singh, James W. Lillard, James W. Lillard
https://patents.justia.com/patent/20040034357
See, e.g., Cohen et al., “Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres,” Pharm. Research, 8:713-20 (1991) (similar to method described above, except that the inner emulsion is poured into and mixed with a polyvinyl alcohol-methylene chloride solution rather than simply a polyvinyl alcohol ...
http://www.freepatentsonline.com/5288502.html
Feb 22, 1994 · What is claimed is: 1. A delivery system for a protein, peptide, or drug with biodegradable multi-phase microspheres, said microspheres comprising a protein, peptide, or drug contained within a fixed oil and an essentially water insoluble, biodegradable polymeric matrix comprised of polylactic acid or polylactic glycolic acid wherein the polymeric matrix surrounds the fixed oil of the ...
http://www.freepatentsonline.com/6726934.html
Apr 27, 2004 · Micro-particulate and nano-particulate polymeric delivery system . United States Patent 6726934 . Abstract: The present invention provides a method of making particles useful in drug delivery, comprising the steps of: contacting polyanionic polymers with cations in a stirred reactor so that polyanions and the cations react to form particles ...
https://patents.google.com/patent/US9339465B2/en
Nucleic acids are prepared by dissolving compounds containing them in a suitable solvent or solvent system and forming microspheres from the resulting solution. The microspheres are administered to an individual as protection from conditions where delivery of nucleic acids is useful, such as in treatment of autoimmune disease.Author: Terrence L. Scott, Debra Lafreniere, Vered Bisker-Leib, Larry R. Brown
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