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https://link.springer.com/article/10.1007/s11051-012-1219-4
Oct 10, 2012 · Major research issues in oral protein delivery include the stabilization of protein in delivery devices which could increase its oral bioavailability. The Surface-modified PLGA nanoparticles were characterized for conjugation efficiency of ligand, shape and surface morphology, particle size, zeta potential, polydispersity index, entrapment efficiency, and in vitro drug release.Author: Pooja Hurkat, Aviral Jain, Ashish Jain, Satish Shilpi, Arvind Gulbake, Sanjay K. Jain
https://www.researchgate.net/publication/234007176_Concanavalin_A_conjugated_biodegradable_nanoparticles_for_oral_insulin_delivery
All the results indicated that the integration of HP55-coated capsule with cationic nanoparticles may be a promising platform for oral delivery of insulin with high bioavailability.
http://adsabs.harvard.edu/abs/2012JNR....14.1219H
Ex vivo study was performed on Wistar rats, which exhibited the higher intestinal uptake of Con A conjugated nanoparticles. In vivo study performed on streptozotocin-induced diabetic rats which indicate that a surface-modified nanoparticle reduces blood glucose level effectively within 4 h of its oral administration.
https://www.springerprofessional.de/en/concanavalin-a-conjugated-biodegradable-nanoparticles-for-oral-i/5652740
Major research issues in oral protein delivery include the stabilization of protein in delivery devices which could increase its oral Concanavalin A conjugated biodegradable nanoparticles for oral insulin delivery springerprofessional.de
https://www.academia.edu/10527166/Concanavalin_A_conjugated_biodegradable_nanoparticles_for_oral_insulin_delivery
Concanavalin A conjugated biodegradable nanoparticles for oral insulin delivery
https://www.sciencedirect.com/science/article/pii/B9780081025482000093
Polymer-coating concanavalin A as glucose-sensitive material, free glucose enters the system and replaces insulin attached to concanavalin A assembly, triggering insulin release. This type of insulin delivery model is composed of phase-reversible hydrogels which change from gel into solution phase when free glucose enters the system.Author: Maria Saeed, Amr Elshaer
https://www.sciencedirect.com/science/article/pii/S073497501500035X
PLGA, an aliphatic polyester co-polymer, is one of the most used synthetic polymer to produce nanoparticles for the oral delivery of insulin, mainly due to its biodegradability and biocompatibility properties as well as sustained release profiles.Author: Pedro Fonte, Francisca Araújo, Cátia Silva, Carla Pereira, Salette Reis, Hélder A. Santos, Bruno Sar...
https://www.researchgate.net/publication/278041012_A_review_of_biodegradable_polymeric_systems_for_oral_insulin_delivery
Natural polymers, such as chitosan and its derivates, alginate derivatives, γ-PGA-based materials and starch-based nanoparticles have been exploited for oral insulin delivery; synthetic polymers ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619439/
Oct 24, 2015 · Using computational analysis, Lassalla et al. showed the presence of hydrophobic and hydrophilic interactions between insulin and PLGA polymer [ 80 ]. PLGA nanoparticles were formulated by a modified solvent diffusion technique as model nanocarriers for insulin and potential oral drug delivery system [ 81 – 83 ].Author: Garima Sharma, Garima Sharma, Ashish Ranjan Sharma, Ju-Suk Nam, George Priya C. Doss, Sang-Soo Lee, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476457/
Moreover, oral insulin is delivered directly to the liver via portal circulation and could generate a high portal-systemic gradient replicating the endogenous secretion of insulin.40 Nevertheless, effective oral insulin delivery remains challenging because of poor bioavailability.41,42 In the gastrointestinal tract, the absorption of protein and peptide molecules is hampered by physical and biochemical barriers (epithelium, variable pH, enzymatic proteolysis, efflux pumps…Author: Elena Matteucci, Ottavio Giampietro, Vera Covolan, Daniela Giustarini, Paolo Fanti, Ranieri Rossi
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