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https://www.researchgate.net/publication/7471358_Commercial_challenges_of_protein_drug_delivery
Commercial challenges of protein drug delivery. ... the commercial successes of protein delivery by the nasal, oral and pulmonary routes have been more opportunistic rather than the application of ...
https://www.researchgate.net/profile/Larry_Brown2/publication/7471358_Commercial_challenges_of_protein_drug_delivery/links/54c8fc040cf238bb7d0eb46b.pdf
Commercial challenges of protein drug delivery 30 Expert Opin. Drug Deliv. (2005) 2(1) 2. Early history of protein delivery 2.1 Blood transfusions The history of protein drug delivery can probably ...
https://www.tandfonline.com/doi/abs/10.1517/17425247.2.1.29
Jul 17, 2018 · Today, commercial successes for protein and peptide delivery systems remain limited. The needle and syringe remain the primary means of protein delivery. Major hurdles remain in order to overcome the combined natural barriers of drug permeability, drug sta-bility, pharmacokinetics and pharmacodynamics of protein therapeutics.Author: Larry R Brown
https://www.medscape.com/viewarticle/770397_5
Nov 01, 2019 · Nanotechnology has the potential to revolutionize drug delivery, but challenges remain. This article summarizes recent developments in the use of nanoparticles as drug delivery systems.
https://www.tandfonline.com/doi/abs/10.1080/03639045.2019.1628770
Despite their therapeutic potential, peptides and proteins pose complex challenges in drug delivery and require scientist to contemplate to achieve suitable delivery system. As most of the commercial products for proteins and peptides are available as a parenteral delivery and freeze drying process is one commonly used technique, it is ...Author: Divisha Jain, S. Shahe Mahammad, Pirthi Pal Singh, Ravinder Kodipyaka
https://www.sciencedirect.com/science/article/pii/S0032386108000487
Hydrogels in drug delivery: Progress and challenges ... drug re-crystallization typically occurs over time, limiting the commercial use of solid molecular dispersions. ... several challenges remain to improve the clinical applicability of hydrogels for drug delivery. One set of major challenges relates to improving the ease of clinical usage ...Author: Todd R. Hoare, Daniel S. Kohane
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664963/
Dec 01, 2015 · Biological challenges facing liposomal drug delivery systems. As with any foreign particle that enters the body, liposomes encounter multiple defense systems aimed at recognition, neutralization, and elimination of invading substances. These defenses include the RES, opsonization, and immunogenicity (Willis and Forssen, 1998).Author: Lisa Sercombe, Tejaswi Veerati, Tejaswi Veerati, Fatemeh Moheimani, Sherry Y. Wu, Anil K. Sood, Susa...
https://www.ncbi.nlm.nih.gov/books/NBK200818/
4 Challenges In Drug Delivery ... effects of silver nanoparticles on HIV infection that showed that silver nanoparticles were able to bind to the gp120 protein on the HIV capsid ... Challenges In Drug Delivery - Technological Challenges in Antibiotic Discovery and Development.Author: Division on Earth
https://www.sciencedirect.com/book/9781907568183/therapeutic-protein-drug-products
The drug product manufacturing process, which includes the process of compounding to filling, is also covered. Methods of delivery in the clinic are addressed, as well as delivery strategies. Finally, a perspective on the regulatory requirements for therapeutic protein formulations is discussed.
https://www.nature.com/articles/nrd1067
Apr 01, 2003 · This article will address the current status and future possibilities of oral macromolecular drug delivery. Challenges for the oral delivery of macromolecules ... for protein and peptide drug ...Author: Michael Goldberg, Isabel Gomez-Orellana
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