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https://www.sciencedirect.com/science/article/pii/S0076687905910185
Cochleates are one of the drug delivery platforms that attracted attention recently as a means to enhance and optimize the delivery of pharmaceuticals (Delmas 2002, Santangelo 2000, Segarra 2002, Zarif 2002, Zarif 2002, Zarif 2000a, Zarif 2000b).Author: Leila Zarif
https://www.tandfonline.com/doi/abs/10.3109/08982100009031116
Jan 25, 2018 · Cochleates are a lipid-based tailored drug delivery system formed by the precipitation of a negatively charged lipid and a cation, for example phosphatidylserine and calcium. Hydrophobic, amphiphilic, negatively or positively charged moieties are suitable candidates to be delivered via cochleates. Various procedures have been developed allowing the control of cochleate particle size, …Author: Leila Zarif, John R. Graybill, David Perlin, Raphael J. Mannino
https://www.ncbi.nlm.nih.gov/pubmed/15721389
Drug delivery technology has brought additional benefits to pharmaceuticals such as reduction in dosing frequency and side effects, as well as the extension of patient life. To address this need, cochleates, a precipitate obtained as a result of the interaction between phosphatidylserine and calcium, have been developed and proved to have potential in encapsulating and delivering small molecule drugs.Author: Leila Zarif
https://www.fiercepharma.com/drug-delivery/matinas-cochleate-drug-delivery-candidate-gets-fda-s-infectious-disease-product-boost
Dec 15, 2015 · The candidate uses the company's flagship cochleate lipid-crystal nanoparticle drug delivery technology to achieve targeted drug delivery, …
https://www.pharmatutor.org/articles/nanocochleate-novel-bypass-of-conventional-drug-elivery-system
Cochleate is most versatile technology for the delivery of a wide range of drugs and fragile molecules such as proteins and peptides. Cochleates are calcium-phospholipid structures composed of naturally occurring materials that “wrap” around the drug or nutrient being introduced into the body.Author: H Vyas, T Upadhyay, N Thakkar, K Patel, U Upadhyay
https://www.pharmatutor.org/pdf_download/pdf/Vol.%202,%20Issue%202,%20Feb%202014,%20PharmaTutor,%20Paper-10.pdf
In particular, cochleate technology was shown to be effective in the therapeutic oral delivery of the hydrophobic drugs, which is negatively charged phospholipids bilayer rolled up by interaction with multi‐cationic metal ions to form a rigid spiral rod. The nanocochleate drug delivery vehicle is based upon encapsulating
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