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https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=2079&context=dissertations_2
INTRACELLULAR PROTEIN DELIVERY, AND CRISPR/CAS9-BASED GENE EDITING ... delivery tools. Briefly, proteins and gold nanoparticles were co-engineered to carry complementary electrostatic recognition elements. When these materials were mixed ... Co-engineering of E-tagged proteins and nanoparticles for direct cytoplasmicAuthor: Rubul Mout
https://pubs.acs.org/doi/abs/10.1021/acsnano.7b02884
Endosomal entrapment is a key hurdle for most intracellular protein-based therapeutic strategies. We report a general strategy for efficient delivery of proteins to the cytosol through co-engineering of proteins and nanoparticle vehicles.Author: Rubul Mout, Moumita Ray, Tristan Tay, Kanae Sasaki, Gulen Yesilbag Tonga, Vincent M. Rotello
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766003/
Jun 27, 2017 · Endosomal entrapment is a key hurdle for most intracellular protein-based therapeutic strategies. We report a general strategy for efficient delivery of proteins to the cytosol through co-engineering of proteins and nanoparticle vehicles.Author: Rubul Mout, Moumita Ray, Tristan Tay, Kanae Sasaki, Gulen Yesilbag Tonga, Vincent M. Rotello
https://scholarworks.umass.edu/dissertations_2/1112/
Inspired by such natural assemblies, I employed molecular engineering approaches to fabricate self-assembled nanostructures to use as intracellular protein delivery tools. Briefly, proteins and gold nanoparticles were co-engineered to carry complementary electrostatic recognition elements.Author: Rubul Mout
http://europepmc.org/articles/PMC5760992
In this protocol, we describe a method for direct cytosolic protein delivery that avoids endosomal entrapment of the delivered proteins. We achieved this by tagging the desired protein with an oligo glutamic acid tag (E-tag), and subsequently using carrier gold nanoparticles to deliver these E-tagged proteins.
https://www.researchgate.net/publication/335698597_Rational_Design_of_Nanocarriers_for_Intracellular_Protein_Delivery
Request PDF Rational Design of Nanocarriers for Intracellular Protein Delivery Protein/antibody therapeutics have exhibited the advantages of high specificity and activity even at an extremely ...
https://www.researchgate.net/publication/326213077_Drug_nanorods_are_potential_new_nanocarriers_for_intracellular_protein_delivery
Intracellular delivery of materials has become a critical component of genome-editing approaches, ex vivo cell-based therapies, and a diversity of fundamental research applications.
https://www.nature.com/articles/s41467-018-03779-8
Apr 10, 2018 · Direct delivery of proteins into cells avoids many drawbacks of gene delivery, and thus has emerging applications in biotherapy. However, it remains a …Author: Zhang Z, Shen W, Yan Y, Hu J, Cheng Y
https://elements.chem.umass.edu/rotellogroup/research/drug-delivery/
We achieved a remarkably high efficient (~90%) direct cytoplasmic/nuclear delivery of Cas9 protein complexed with a single guide RNA (sgRNA) through the co-engineering of Cas9 protein and carrier nanoparticles. In our approach, we engineered the Cas9 protein to carry a long glutamic acid tag (E-tagged Cas9 or Cas9En).
http://pubsdc3.acs.org/doi/full/10.1021/bc500320j
Intracellular delivery of specific proteins and peptides may be used to influence signaling pathways and manipulate cell function, including stem cell fate. Herein, we describe the delivery of proteins attached to hydrophobically modified 15-nm silica nanoparticles to manipulate specifically targeted cell signaling proteins.Author: Ailing Fu, Rui Tang, Joseph Hardie, Michelle E. Farkas, Vincent M. Rotello
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