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https://www.sciencedirect.com/science/article/pii/S0168165615000115
Here we report a proof of concept study in the technical development of a co-culture in vitro model of human medulloblastoma to use as an assessment tool for drug delivery. The model utilises the UW228-3 cell line and human foetal brain tissue cultured as neurospheres in defined serum-free stem cell media.Author: Delyan P. Ivanov, Terry L. Parker, David A. Walker, Cameron Alexander, Marianne B. Ashford, Paul R. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436947/
Dec 10, 2012 · Co-culture spheroids are formed with two or more cell types in varying ratios representing intercellular signaling and architecture seen in vivo. These co-culture spheroids can help decipher how multiple cell types found in tissues in vivo might impact drug delivery.Author: Geeta Mehta, Amy Y. Hsiao, Marylou Ingram, Gary D. Luker, Shuichi Takayama, Shuichi Takayama
https://elrig.org/downloads/ri15/ELRIG_DelyanIvanov.pdf
Co-culture models •Mimics interaction between normal and tumour tissue •Cells marked with supravital stains (CDCFDA SE, CellTrace) •Maintains tissue heterogeneity Ultra low attachment 96-well plate Co-culture ready for compound screening Green- normal cells Blue- tumour cells Seed cell suspension Spheroid formation 3 days
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289391/
Sep 28, 2016 · Transport of nanorods across the intestinal co-culture was also significantly higher than spheres. The findings indicate that nanoparticle-mediated oral drug delivery can be potentially improved with departure from spherical shape which has been traditionally utilized for …Author: Amrita Banerjee, Jianping Qi, Jianping Qi, Rohan Gogoi, Jessica Wong, Samir Mitragotri
http://www.altex.ch/resources/Kletting_of_171123.pdf
Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines1 Stephanie Kletting 1, Sarah Barthold , Urska Repnik 3, Gareth Griffiths , Brigitta Loretz1, Nicole Schneider-Daum1,Cristiane de Souza Carvalho-Wodarz1 and Claus-Michael Lehr1,2 1Department Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Saarland University,
https://www.sciencedirect.com/topics/engineering/drug-delivery
Drug delivery is a process of administering a pharmaceutical compound to bring about therapeutic effects in patients. Drug delivery technology evolved to become an integral tool for the enhancement of pharmacoki-netic properties of drugs, minimization of harmful side effects, and bringing about superior clinical outcomes.
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in …
https://aiche.onlinelibrary.wiley.com/doi/pdf/10.1002/btm2.10079
Canonical drug delivery research usually commences with the valida- tion of a carrier or a drug using in vitro static cell cultures in which cells are grown in 2D monolayers and are subjected to the drug and subse- quently tested through a variety of established methods for cellularAuthor: Maria Jarvis, Michael Arnold, Jenna Ott, Kapil Pant, Balabhaskar Prabhakarpandian, Samir Mitragotri
https://www.cell.com/matter/fulltext/S2590-2385(19)30165-1
The local drug delivery depot with high biocompatibility to the TME is highly desired for clinical applications. Adipocytes are widely present in the human body, and the procedures including isolation, purification, and differentiation of preadipocytes are straightforward and robust.Author: Di Wen, Di Wen, Jinqiang Wang, Jinqiang Wang, George Van Den Driessche, Qian Chen, Qian Chen, Yuqi Z...
https://www.medindia.net/patients/patientinfo/drug-delivery-system.htm
Drug delivery systems, is a technology using various chemicals to bind the target drugs, carry them to target organ, tissue or cell where the drug is released at a pre-determined rate.
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