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https://grants.nih.gov/grants/guide/pa-files/PAR-18-895.html
Understanding of the BBB and drug transport has improved over the years, and drug delivery technologies, including CNS-targeted platforms, have become one of the key focus areas of modern science. This solicitation is specifically designed to address CNS-targeted drug delivery for HIV and reflects the long-term goals of the National Institutes of Health to develop next generation HIV therapies.
https://www.niaid.nih.gov/grants-contracts/cns-targeted-drug-delivery
Apply to explore novel central nervous system (CNS)-targeted drug delivery platforms and focus on product development activities to identify and eliminate CNS viral reservoirs that potentially lead toward a cure or lifelong remission of HIV infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026551/
May 10, 2014 · Townsend et al found that TTC-conjugated NPs have a strong affinity for neurons in the periphery,24 which could be used as an efficient drug delivery vehicle targeted to the CNS via retrograde transport.Author: Cui-Tao Lu, Ying-Zheng Zhao, Ho Lun Wong, Jun Cai, Lei Peng, Xin-Qiao Tian
https://www.sciencedirect.com/book/9780128140017/brain-targeted-drug-delivery-system
With our advancement in understanding the physiological features of the BBB, various CNS-targeted drug delivery strategies have been developed, including BBB disruption, drug modification, and carrier (nanoparticles or cells)-based drug delivery systems to improve drug transport across the BBB to treat CNS …
https://www.medlink.com/article/drug_delivery_to_the_central_nervous_system
The major obstruction to CNS drug delivery is the blood-brain barrier, which limits the access of drugs to the brain substance. This article describes various strategies to facilitate drug delivery to the brain in neurologic disorders. Most of these involve methods to penetrate the blood-brain barrier or to bypass it.
https://www.researchgate.net/publication/23796829_CNS_Drug_Delivery_Systems_Novel_Approaches
Targeted drug delivery is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others.
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