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https://www.sciencedirect.com/science/article/pii/S0168365901004886
Jan 17, 2002 · This report describes our experience on enhancement of drug delivery to solid tumors. Results of our preclinical and clinical studies including a randomized prospective phase III trial have validated the concept that enhanced drug delivery can significantly improve the treatment efficacy of intravesical mitomycin C therapy of superficial bladder cancer.Author: Jessie L.-S Au, Seong H Jang, M.Guill Wientjes
https://www.researchgate.net/publication/11586298_Clinical_aspects_of_drug_delivery_to_tumors
However, inadequate drug delivery to solid tumors is a major reason for treatment failure in systemic and IPC strategies [1, 2]. One of the assumed reasons is an increased intratumoral pressure ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272876/
Aug 10, 2011 · The bottom line is that “passive targeting” is a misnomer. Rather there is simply distribution of drug or drug delivery system by blood circulation. The term “passive targeting” needs to be replaced with “blood circulation and extravasation,” which is not limited to drug delivery to tumors.Author: You Han Bae, Kinam Park
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634382/
Oct 05, 2017 · These nanocarriers have brought a revolution in cancer drug delivery by targeting tumor explicitly with enriched permeability and withholding effect as much as required. These exciting progressions in cancer therapy and exclusive development of numerous novel drug delivery systems have augmented the hope of those fighting against tumors.Author: Fakhar ud Din, Waqar Aman, Izhar Ullah, Omer Salman Qureshi, Omer Mustapha, Shumaila Shafique, Alam ...
https://www.sciencedirect.com/science/article/pii/0037198X84900312
Brain Tumors: Clinical Aspects By John M. Tew, Jr., John H. Feibel, and Raymond Sawaya BRAIN tumor, one of the most dreaded medi- cal conditions, may occur as a primary lesion arising in the brain or its coverings or may be metastatic from other locations throughout the body. unlike other malignant neoplasms, primary brain tumors rarely spread to areas outside the brain.Author: John M. Tew, John H. Feibel, Raymond E Sawaya
https://clincancerres.aacrjournals.org/content/25/7/2024
Apr 01, 2019 · In this issue of Clinical Cancer Research, Wang and colleagues demonstrate that shear modulus, a measure of tissue stiffness measured using elastography, correlates with drug delivery in two orthotopic mouse models of pancreatic tumors ().Although increased matrix density can cause increased stiffness and hinder drug delivery, there are other aspects of the physical tumor microenvironment ...Author: Hadi T. Nia, Lance L. Munn, Rakesh K. Jain
https://www.tandfonline.com/doi/abs/10.1080/17425247.2018.1547279
Aug 27, 2018 · Specialized microbubbles and ultrasound transducers are being developed for drug delivery and therapeutic applications. As sonopermeation is being established as one of many treatment options, it will be important to develop tools to stratify tumors and patients, to include only those who are most likely to respond in (initial) clinical trials.Author: Sofie Snipstad, Sofie Snipstad, Einar Sulheim, Einar Sulheim, Catharina de Lange Davies, Chrit Moone...
https://cancerres.aacrjournals.org/content/66/8/3967
Apr 15, 2006 · Introduction. In his opening remarks to the attendees, conference chair Dr. Rakesh Jain summarized the milestones in angiogenesis and drug delivery research, the importance of addressing them in the same meeting, and the relevance of having Boston as a most fitting place to organize it.Author: Dan G. Duda
https://research.utwente.nl/en/publications/sonopermeation-to-improve-drug-delivery-to-tumors-from-fundamenta
Areas covered: In this review, we summarize various in vitro assays and in vivo setups that have been employed to unravel the fundamental mechanisms involved in ultrasound-enhanced drug delivery, as well as clinical trials that are ongoing in patients with brain, pancreatic, liver and breast cancer.Author: Sofie Snipstad, Sofie Snipstad, Einar Sulheim, Einar Sulheim, Catharina de Lange Davies, Chrit Moone...
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