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http://www.authorstream.com/Presentation/mammi014-2885978-chronotherapeutic-drug-delivery-system/
Aug 09, 2016 · LIMITATIONS OF PULSATILE DRUG DELIVERY SYSTEM : Pulsatile drug delivery system have certain limitation, so in many cases these drug delivery system is fails, • Multiple manufacturing steps in case of Multi particulate pulsatile drug delivery system. • Low drug load • Incomplete release • In-vivo variability in single unit pulsatile drug ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637939/
Local drug delivery can establish the same kind of systemic levels but very different concentrations gradients – extremely high at the point of drug release and in nearby tissues and far lower elsewhere. 24,25 Dose may dictate net effect but concentration gradients drive drug transport and it is then possible for the local and systemic ...Author: Mark A. Lovich, Abraham E. Wei, Mikhail Y. Maslov, Peter I. Wu, Elazer R. Edelman
https://www.drugs.com/drug-class/anticholinergic-chronotropic-agents.html
Anticholinergic chronotropic agents are also known as muscarinic antagonists or parasympatholytic. All of them are competitive antagonists, and selectively block the effects of parasympathetic nerve activity. They block cardiac muscarinic receptors and cause tachycardia. They also have effect on other body systems such as inhibition of ...
https://quizlet.com/118382589/cardiac-drugs-inotropic-chronotropic-dromotropic-flash-cards/
Start studying CARDIAC DRUGS (inotropic, chronotropic, dromotropic). Learn vocabulary, terms, and more with flashcards, games, and other study tools.
http://www.authorstream.com/Presentation/chinmayeechinni-1521280-colon-drug-delivery-system/
Aug 29, 2012 · COLON DRUG DELIVERY SYSTEM - authorSTREAM Presentation. Gastro intestinal transit time.: Gastro intestinal transit time. The arrival of oral dosage form at the colon is determined by the rate of gastric emptying & small intestinal transit time.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646071/
Oct 28, 2013 · Local drug delivery preferentially loads target tissues with a concentration gradient from the surface or point of release that tapers down to more distant sites. Drug that diffuses down this gradient must be in unbound form, but such drug can only elicit ...Author: Mikhail Y. Maslov, Elazer R. Edelman, Abraham E. Wei, Matthew J. Pezone, Mark A. Lovich
http://impactfactor.org/PDF/IJPCR/2/IJPCR,Vol2,Issue1,Article2.pdf
specific time and site resulted into novel type of drug delivery systems, ‘chronotropic or pulsatile drug delivery systems”. The principle rationale behind designing these delivery systems is to release the drug at desired time as per the pathophysiological need of disease, resulting in improved patient therapeutic efficacy and compliance.
https://www.britannica.com/science/chronotropic-agent
Learn about this topic in these articles: major reference. In cardiovascular drug: Effects on heart function …heartbeat, or heart rate (chronotropic effects); or they can affect the regularity of the heartbeat (rhythmic effects).
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