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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649783/
Conventional drug delivery system of valsartan is inappropriate for the delivery of drug, as they cannot be administered just before the symptoms are worsened. Bedtime dosing of conventional drug dosage of valsartan will not provide a sufficient therapeutic plasma drug concentration at the early hours of morning.
http://ijpsr.com/bft-article/development-and-evaluation-of-chronomodulated-pulsincap-drug-delivery-system-of-ketoprofen/?view=fulltext
ABSTRACT: Chronotherapeutic drug delivery systems have been recognized as potentially beneficial to the chrono-therapy (time optimized) of chronic diseases that display time-dependent symptoms.In pulsincap system, therapy can be optimized by tailoring the dosing schedule based on chrono-biological pattern. The safety and efficacy of the drug is achieved by coordinating the peak plasma ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465150/
Conventional drug delivery system of captopril is inappropriate for the delivery of drug, as they cannot be administered just before the symptoms are worsened, because during this time the patients are asleep, bedtime dosing of captopril will not provide a therapeutic plasma drug concentration at the early hours of morning because of poor ...
https://www.sciencedirect.com/science/article/pii/S1110093117300649
Pulsatile drug delivery system is time and site-specific drug delivery system, thereby providing special and temporal delivery and increasing patient compliance. Pulsatile drug delivery system is defined as the rapid and transient release of certain amount of molecules within a short time period immediately after a predetermined off-release ...Author: Komal Parmar, Almas Shaikh, Hitesh Dalvadi
https://www.researchgate.net/publication/232257562_Development_and_characterization_of_chronomodulated_drug_delivery_system_of_captopril
Thus, this study attempts to design and evaluate a chronomodulated pulsatile drug delivery system of captopril which was aimed to release the drug after a lag time of 6 hours.
https://www.sciencedirect.com/science/article/abs/pii/S1110093117300649
Mathematical modeling for kinetic studies revealed that the release profile after lag time followed first order kinetics. Accelerated stability studies for one month at 40 ± 2 °C/75 ± 5% RH showed no remarkable changes concluding that a successful pulsatile …Author: Komal Parmar, Almas Shaikh, Hitesh Dalvadi
https://www.researchgate.net/publication/40834798_Chronomodulated_Drug_Delivery_System_of_Salbutamol_Sulphate_for_the_Treatment_of_Nocturnal_Asthma
J. Ali et al [38] have developed a Chronomodulated Drug Delivery System of Salbutamol Sulphate for the Treatment of Nocturnal Asthma. They have designed a rupturable pulsatile drug delivery system ...
https://www.slideshare.net/revathireddypharma/chronotherapeutics-and-chronomodulated-drug-delivery-system
Dec 26, 2011 · CHRONOMODULATED DRUG DELIVERY SYSTEMS1. The pulsatile drug delivery system• Pulsatile drug release is a system where the drug is released suddenly after a well-defined lag time or time gap according to the circadian rhythm of disease states. • No drug is released from the device within this lag time.•
https://juniperpublishers.com/downloadPdf.php?folder=gjpps&file=GJPPS.MS.ID.555551
(NA) [10]. A drug delivery system administered at bedtime but releasing drug during morning hours would be ideal in this case. Nocturnal asthma is a variable exacerbation of the underlying asthma condition associated with increases in symptoms, need for medication, airway …
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