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https://www.sciencedirect.com/science/article/pii/S0169409X01001983
These gene delivery systems based on chitosans can also be equipped with ligands for specific cell interaction, such as transferrin or galactose. A number of in vitro and in vivo studies showed that chitosan is a suitable material for efficient non-viral gene and DNA vaccine delivery.Author: Gerrit Borchard
https://www.sciencedirect.com/science/article/abs/pii/S0169409X01001983
Nov 05, 2001 · Efficient non-viral gene delivery based on cationic polymers as DNA-condensing agents is dependent on a variety of factors, e.g. complex size, complex stability, toxicity, immunogenicity, protection against DNase degradation, and intracellular trafficking and processing of the DNA.Author: Gerrit Borchard
https://www.deepdyve.com/lp/elsevier/chitosans-for-gene-delivery-04tgfse3nh
Nov 05, 2001 · Chitosans for gene delivery Chitosans for gene delivery Borchard, Gerrit 2001-11-05 00:00:00 Efficient non-viral gene delivery based on cationic polymers as DNA-condensing agents is dependent on a variety of factors, e.g. complex size, complex stability, toxicity, immunogenicity, protection against DNase degradation, and intracellular trafficking and processing of the DNA.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627531/
Jun 25, 2019 · The success of a gene therapy strongly depends on the gene delivery systems, which should possess the following characteristics: targeting of the specific cells, low cytotoxicity, high gene delivery capacity, protection of gene cargo, sustained-release of the gene, escape capability from lysosome, and high transfection efficiency.Author: Ye Cao, Yang Fei Tan, Yee Shan Wong, Melvin Wen Jie Liew, Subbu Venkatraman
http://www.nature.com/articles/3301492
Jul 13, 2001 · This study was designed to provide further insight into the in vitro and in vivo properties of chitosan as a DNA-condensing nonviral gene delivery system. First, chitosans of different, well ...Author: Magnus Köping-Höggård, Ioannis Tubulekas, Holly Guan, Katarina Edwards, Mats Nilsson, Kjell Mårten V...
https://www.ncbi.nlm.nih.gov/pubmed/23676471/
May 15, 2013 · The application of gene therapy to the field of orthopaedic tissue engineering is extremely promising as the controlled release of therapeutic proteins such as bone morphogenetic proteins have been shown to stimulate bone repair. However, there are a number of drawbacks associated with viral and synthetic non-viral gene delivery approaches.Author: Rosanne Raftery, Fergal J. O'Brien, Sally-Ann Cryan
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