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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626781/
In a previous study, we reported briefly on the potential of chitosan-dextran sulfate nanoparticles (CDNs) as a candidate system for ocular drug delivery . Chitosan (CS) is an ideal polymeric carrier because it is biocompatible, biodegradable, non-toxic, and bioadhesive, and possesses a high positive charge density.Author: Wanachat Chaiyasan, Sangly P. Srinivas, Waree Tiyaboonchai
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693026/
Jun 18, 2013 · Ocular drug transport barriers pose a challenge for drug delivery comprising the ocular surface epithelium, the tear film and internal barriers of the blood-aqueous and blood-retina barriers. Ocular drug delivery efficiency depends on the barriers and the clearance from the choroidal, conjunctival vessels and lymphatic.Author: Hong-Yan Zhou, Ji-Long Hao, Shuang Wang, Yu Zheng, Wen-Song Zhang
https://www.intechopen.com/books/chitin-chitosan-myriad-functionalities-in-science-and-technology/chitosan-a-good-candidate-for-sustained-release-ocular-drug-delivery-systems
Thus, chitosan is a good excipient either for classic drop-type ocular systems, as well as for complex drug systems such as nanostructures (nanoparticles, nanomicelles and nanosuspensions), liposomes, microemulsions, microspheres, in situ hydrogels and inserts or implants.Author: Lăcrămioara Popa, Mihaela Violeta Ghica, Cristina Elena Dinu-Pîrvu, Teodora Irimia
https://www.sciencedirect.com/science/article/pii/S0939641112001038
Due to its nontoxic character, permeation enhancing properties, and physicochemical characteristics, chitosan is a suitable material for the design of ocular drug delivery systems. Chitosan-based formulations used for ophthalmic drug delivery are hydrogels , nanoparticles , and coated colloidal systems . Chitosan-based systems have the ...Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
https://www.researchgate.net/publication/8527231_Chitosan_Nanoparticles_as_New_Ocular_Drug_Delivery_Systems_In_Vitro_Stability_in_Vivo_Fate_and_Cellular_Toxicity
To assess the potential of chitosan (CS) nanoparticles for ocular drug delivery by investigating their interaction with the ocular mucosa in vivo and also their toxicity in conjunctival cell cultures.
https://www.researchgate.net/publication/24205168_Chitosan_nanoparticles_for_drug_delivery_to_the_eye
Chitosan nanoparticles for drug delivery to the eye Article · Literature Review in Expert Opinion on Drug Delivery 6(3):239-53 · April 2009 with 141 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S0378517311003589
Development of efficient ocular delivery nanosystems remains a major challenge to achieve sustained therapeutic effect. The purpose of this work was to develop chitosan nanoparticles using sulfobutylether-β-cyclodextrin (SBE-β-CD) as polyanionic crosslinker and to investigate the potential of using those nanostructures as ocular drug delivery systems.Author: Azza A. Mahmoud, Gina S. El-Feky, Rabab Kamel, Ghada E.A. Awad
https://www.pharmaexcipients.com/news/chitosan-nanoparticles-as-a-mucoadhesive-drug-delivery-system-for-ocular-administration/
The formulation was stable and the drug active, as shown by microbiological studies. In conclusion, chitosan/TPP-hyaluronic acid nanoparticle eye drop formulations are a promising platform for ocular drug delivery with enhanced mucoadhesive properties. Conclusions
https://onlinelibrary.wiley.com/doi/pdf/10.1211/0022357022476
ocular drug delivery systems. Accordingly, we will first comment on the therapeutic role of chitosan in ophthal-mology and then, following a brief presentation of the barriers that need to be overcome in ocular drug delivery, we will illustrate, with a number of examples, the potential that chitosan offers to resolve such limitations. TheseAuthor: María José Alonso, Alejandro Sánchez
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