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https://www.sciencedirect.com/science/article/pii/S0001868618303865
Gene therapy is a promising strategy for treating challenging diseases. The successful delivery of genes is a critical step for gene therapy. However, concerns about immunogenicity and toxicity are the main obstacles against the widespread use of effective viral systems.Author: Di Chuan, Tao Jin, Rangrang Fan, Liangxue Zhou, Gang Guo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627531/
Jun 25, 2019 · Although chitosan offers several favourable characteristics as an excellent gene carrier, unmodified chitosan is restricted by its low solubility in physiological conditions. Therefore, chitosan derivatives with enhanced solubility compared to chitosan for gene delivery have been well explored and summarized in several reviews [24,25,26].Author: Ye Cao, Yang Fei Tan, Yee Shan Wong, Melvin Wen Jie Liew, Subbu Venkatraman
https://www.ncbi.nlm.nih.gov/pubmed/30933750
Chitosan for gene delivery: Methods for improvement and applications. Chuan D(1), Jin T(2), Fan R(1), Zhou L(1), Guo G(3). Author information: (1)State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China.Author: Di Chuan, Tao Jin, Rangrang Fan, Liangxue Zhou, Gang Guo
https://www.sciencedirect.com/science/article/pii/S0939641112001038
As chitosan is comparatively less toxic than other cationic polymers such as polyethyleneimine, polylysine, or polyarginine , it is therefore a promising excipient for non-viral gene delivery systems. In addition, chitosan–DNA-based drug complexes protect at least to some extend towards degradation by DNAses in this way improving the ...Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
http://www.nature.com/articles/3301492
Jul 13, 2001 · Chitosan is a natural cationic linear polymer that has recently emerged as an alternative nonviral gene delivery system. We have established the relationships between the structure and the ...Author: Magnus Köping-Höggård, Ioannis Tubulekas, Holly Guan, Katarina Edwards, Mats Nilsson, Kjell Mårten V...
https://www.researchgate.net/publication/49660944_Chitosan_and_its_derivatives_for_gene_delivery
Chitosan and its derivatives for gene delivery Article · Literature Review in International journal of biological macromolecules 48(2):234-8 · March 2011 with 161 Reads How we measure 'reads'
https://www.hindawi.com/journals/jnm/2014/246347/
The low gene transfer efficiency of chitosan-DNA polyplexes is a consequence of their high stability and consequent slow DNA release. The incorporation of an anionic polymer is believed to loosen chitosan interactions with DNA and thus promote higher transfection efficiencies. In this work, several formulations of chitosan-DNA polyplexes incorporating hyaluronic acid were prepared and ...Author: Ana V. Oliveira, Diogo B. Bitoque, Gabriela A. Silva
https://www.hindawi.com/journals/jnm/2011/952060/
Poly(D,L-lactide-co-glycolide-) (PLGA-)chitosan nanoparticles are becoming an increasingly common choice for the delivery of nucleic acids to cells for various genetic manipulation techniques. These particles are biocompatible, with tunable size and surface properties, possessing an overall positive charge that promotes complex formation with negatively charged nucleic acids. This study ...Author: Hali Bordelon, Alexandru S. Biris, Cristina M. Sabliov, W. Todd Monroe
https://www.researchgate.net/publication/299975169_Chitosan_Gene_Delivery
Gene delivery is the most innovative therapeutic method in the fi eld of molecular medicine. Viral and nonviral vectors, which are the carrier systems for the gene transfer, are used for the gene ...
https://link.springer.com/chapter/10.1007%2F978-3-662-47862-2_22
An efficient gene delivery system for cellular uptake of DNA is essential for gene therapy. Chitosan has been widely used as a promising non-viral carrier for gene delivery. It is a cationic polymer with free amino groups and can bind to anionic nucleic acids spontaneously.Author: Julide Akbuga, Suna Ozbas-Turan, Ceyda Ekentok
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