Chitosan-Based Vector/Dna Complexes For Gene Delivery

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Chitosan-Based Vector/DNA Complexes for Gene Delivery ...

    https://link.springer.com/article/10.1023%2FA%3A1011981000671
    Sep 01, 1998 · Purpose.Chitosan, a natural cationic polysaccharide, is a candidate non-viral vector for gene delivery. With the aim of developing this system, various biophysical characteristics of chitosan-condensed DNA complexes were measured, and transfections were performed.Author: Patrick Erbacher, Shaomin Zou, Thierry Bettinger, Anne-Marie Steffan, Jean-Serge Remy

Chitosan and its derivatives—a promising non-viral vector ...

    https://www.sciencedirect.com/science/article/pii/S016836590200144X
    What’s more, some encouraging results have been reported on in vivo administration routes of chitosan-based gene transfection system, such as oral, nasal and intravenous administration , . However, in our opinion, to gaining a deep insight into the transfection mechanism of chitosan-based non-viral vectors, several critical problems need to ...Author: Wen Guang Liu, Kang De Yao

Combining hyaluronic acid with chitosan enhances gene ...

    https://www.thefreelibrary.com/Combining+hyaluronic+acid+with+chitosan+enhances+gene+delivery.-a0423500201
    Although chitosan-based polyplexes (complexes of chitosannucleic acids) have desirable characteristics for gene therapy such as efficient nucleic acid encapsulation and protection against degradation, they show low gene transfer efficiency, which is the major obstacle to its use as a gene therapy vector [1,4].

Combining Hyaluronic Acid with Chitosan Enhances Gene Delivery

    https://www.hindawi.com/journals/jnm/2014/246347/
    Although chitosan-based polyplexes (complexes of chitosan-nucleic acids) have desirable characteristics for gene therapy such as efficient nucleic acid encapsulation and protection against degradation, they show low gene transfer efficiency, which is the major obstacle to its use as a gene therapy vector [1, 4].Author: Ana V. Oliveira, Diogo B. Bitoque, Gabriela A. Silva

Enhanced Gene Delivery Mediated by Low Molecular Weight ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929434/
    Enhanced Gene Delivery Mediated by Low Molecular Weight Chitosan/DNA Complexes: Effect of pH and Serum ... Erbacher P, Zou S, Bettinger T, Steffan AM, Remy JS. Chitosan-based vector/DNA complexes for gene delivery: Biophysical characteristics …Author: Surendra Nimesh, Marc M. Thibault, Marc Lavertu, Michael D. Buschmann

Effects of alginate inclusion on the vector properties of ...

    https://www.sciencedirect.com/science/article/pii/S0168365906004299
    Oct 27, 2006 · Overall, alginate inclusion improved the vector properties of chitosan-based nanoparticles, demonstrating superior transfection ability while maintaining biocompatibility and low toxicity. ... A.M. Steffan, J.S. RemyChitosan-based vector/DNA complexes for gene delivery: biophysical ... H. Dai, Y. Liu, C. He, K.W. LeongPEI-g-chitosan, a novel ...Author: Kimberly L. Douglas, Ciriaco A. Piccirillo, Maryam Tabrizian

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