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https://www.ncbi.nlm.nih.gov/pubmed/23965281
Nov 28, 2013 · Moreover, chitosan is biocompatible and biodegradable, which make it a good candidate for siRNA delivery in vivo. However, chitosan requires further development to achieve high efficiency. This review will describe the major barriers that impair the efficiency of the chitosan-based siRNA delivery systems, including the stability of the delivery system in biological fluids and endosomal escape.Author: Héloïse Ragelle, Gaëlle Vandermeulen, Véronique Préat
https://www.sciencedirect.com/science/article/pii/S0168365913004628
Chitosan-based siRNA delivery is typically characterized by in vivo instability and insufficient siRNA intracellular release. A better understanding of these barriers is required for the development of more efficient siRNA delivery systems.Author: Héloïse Ragelle, Gaëlle Vandermeulen, Véronique Préat
https://www.sigmaaldrich.com/catalog/papers/23965281
Recently, chitosan has attracted significant attention in the formulation of small interfering RNA (siRNA). Because of its cationic nature, chitosan can easily complex siRNA, thus readily forming nanoparticles. Moreover, chitosan is biocompatible and biodegradable, which make it a good candidate for siRNA delivery in vivo.
https://www.researchgate.net/publication/256075663_Chitosan-based_siRNA_delivery_systems
Moreover, chitosan is biocompatible and biodegradable, which makes it a good candidate for siRNA delivery in vivo. However, chitosan requires further development to achieve high efficiency.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627531/
Jun 25, 2019 · To address the toxicity issue, chitosan-based carriers have gained increasing interest as a safe delivery system for gene materials including plasmid DNA (pDNA), oligonucleotides and siRNA. Unlike other cationic polymers, chitosan has several advantages such as low toxicity (LD 50 :16 g/kg, while LD 50 for NaCl is 3 g/kg) [ 14 ], low immunogenicity, excellent biocompatibility as well as a …Author: Ye Cao, Yang Fei Tan, Yee Shan Wong, Melvin Wen Jie Liew, Subbu Venkatraman
https://www.sciencedirect.com/science/article/abs/pii/S0169409X09002816
Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro and in vivo for DNA and siRNA delivery systems because of their cationic charge, biodegradability and biocompatibility, as well as their mucoadhesive and permeability-enhancing properties. However, the transfection efficiency of chitosan is too low for clinical application.
https://www.sciencedirect.com/science/article/pii/S0939641112001038
Chitosan-based formulations used for ophthalmic drug delivery are hydrogels , nanoparticles , and coated colloidal systems . Chitosan-based systems have the potential for improving the retention and biodistribution of drugs applied topically onto the eye.Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680562/
Jul 15, 2019 · At present, lipid-based siRNA delivery systems are clearly the most studied non-viral vectors, with several formulations in late stage clinical trials, such as lumasiran and givosiran , as well as patisiran (Onpattro, Alnylam Pharmaceuticals): the first-ever siRNA therapy approved by the FDA on 10 August 2018 [27,28].
https://www.sciencedirect.com/science/article/pii/S0168365913009681
Based on these findings, publications have reported the design of improved chitosan-based delivery system to bypass the polymer limitations and therefore to increase the efficiency of the carrier , , , , . In this study, we aimed at developing chitosan-based nanoparticles suitable for an intravenous administration of siRNA.Author: Héloïse Ragelle, Raphaël Riva, G. Vandermeulen, B. Naeye, Vincent Pourcelle, C. S. Le Duff, C. D'Hae...
https://www.ncbi.nlm.nih.gov/pubmed/19796660
Jan 31, 2010 · Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro and in vivo for DNA and siRNA delivery systems because of their cationic charge, biodegradability and biocompatibility, as well as their mucoadhesive and permeability-enhancing properties.Author: Shirui Mao, Wei Sun, Thomas Kissel
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