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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676798/
Calcium phosphate nanoparticles (nanoCaP) conjugated with cis-diamminedichloro-platinum (CDDP, cisplatin) were prepared through the electrostatic binding of an aquated species of cisplatin to the nanoCaP in a chloride-free solution.The agglomeration of the nanoCaP that typically occurs during synthesis of CaP was controlled through the addition of DARVAN ® 811 immediately after precipitation ...Author: Xingguo Cheng, Liisa Kuhn
https://www.researchgate.net/publication/5648984_Chemotherapy_Drug_Delivery_From_Calcium_Phosphate_Nanoparticles
Chemotherapy Drug Delivery From Calcium Phosphate Nanoparticles Article in International Journal of Nanomedicine 2(4):667-74 · February 2007 with 46 Reads How we measure 'reads'
http://europepmc.org/articles/PMC2676798
Keywords: calcium phosphate, cisplatin, chemotherapy, nanoparticle, drug delivery Introduction Attachment of a pharmaceutical to a particulate drug delivery system is a tactic that has long been employed to sustain drug delivery.
https://www.dovepress.com/chemotherapy-drug-delivery-from-calcium-phosphate-nanoparticles-peer-reviewed-article-IJN
Jan 15, 2008 · Direct addition cytotoxicity studies revealed that the sterically-stabilized, negatively-charged drug nanoconjugates are unable to overcome drug resistance and had an increased IC50 value as compared to the free drug. Keywords: calcium phosphate, cisplatin, …
https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201700060
Herein, we report a facile strategy to prepare supported lipid‐bilayer‐coated polyacrylic acid/calcium phosphate nanoparticles (designated as PAA/CaP@SLB NPs) as a new dual pH‐responsive drug‐delivery platform for cancer chemotherapy.Author: Xin Wang, Manjie Zhang, Lingyu Zhang, Lu Li, Shengnan Li, Chungang Wang, Zhongmin Su, Yue Yuan, Weis...
https://www.sciencedirect.com/science/article/pii/B9780081026809000135
Calcium phosphate nanoparticles have been studied for delivery of the chemotherapy agent, cisplatin. The nanoconjugate was prepared by electrostatic binding of cisplatin to the nanocalcium phosphate. The drug released from the nanoconjugate was equally effective as the free drug against the A2780cis cell line ( Cheng and Kuhn, 2007 ).Author: Willi Paul, Chandra P. Sharma
https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=6703&context=dissertations
Selection of a Nanoparticle Stabilizer for a Calcium Phosphate Drug Delivery System Jessica Lea Woodman, Ph.D. University of Connecticut, 2014 Overall cancer survival rates steadily decline each year following diagnosis and side effects of chemotherapy restrict its use. The chemotherapeutic cis-diamminedichloro-platinum (cisplatin,Author: Jessica L Woodman
https://www.researchgate.net/publication/8524392_Interactions_of_cisplatin_with_calcium_phosphate_nanoparticles_In_vitro_controlled_adsorption_and_release
Most of these studies have fallen short in demonstrating the desired characteristics of a drug delivery vehicle for calcium phosphate nanoparticles, especially in terms of size and col- loidal ...
https://www.sciencedirect.com/science/article/pii/S0939641119304874
Dual delivery of nucleic acids and PEGylated-bisphosphonates via calcium phosphate nanoparticles. ... their poor cellular permeability and preferential bone accumulation hamper their full application in chemotherapy. Here, we investigated the dual delivery of plasmid DNA and alendronate using CaP nanoparticles, with the goal to facilitate ...Author: Sofia Bisso, Simona Mura, Bastien Castagner, Patrick Couvreur, Jean-Christophe Leroux
https://link.springer.com/article/10.1007%2Fs40820-017-0155-3
Oct 13, 2017 · Multifunctional nanoparticles (NPs) with complementary capacities of multimodal imaging and therapeutic functions have drawn extensive attention in biomedical areas [1,2,3,4,5,6].Nowadays, calcium phosphate (CaP) NPs have gained increasing attention in anticancer drug delivery because of their excellent biocompatibility and pH-sensitivity, originating from their chemical nature and mimics …Author: Guilan Li, Yidan Chen, Lingyu Zhang, Manjie Zhang, Shengnan Li, Lu Li, Tingting Wang, Chungang Wang
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