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https://www.researchgate.net/publication/285260721_Chemical_Modification_of_Chitosan_for_Delivery_of_DNA_and_siRNA
Request PDF On Feb 17, 2012, You-Kyoung Kim and others published Chemical Modification of Chitosan for Delivery of DNA and siRNA Find, read and cite …
https://www.sciencedirect.com/science/article/pii/S0169409X09002816
Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro and in vivo for DNA and siRNA delivery systems because of their cationic charge, biodegradability and biocompatibility, as well as their mucoadhesive and permeability-enhancing properties. However, the transfection efficiency of chitosan is too low for clinical application.Author: Shirui Mao, Wei Sun, Thomas Kissel
https://www.sciencedirect.com/science/article/pii/B9780128002681000068
The objective of this chapter is to summarize the recent progress in chitosan and its derivatives as gene (DNA or siRNA) carriers for gene therapy. The roles of chemical modification using cell-specific ligand and stimuli-response group for the enhancement of cell specificity and transfection efficiency in vitro and in vivo are also discussed. 2.Author: Hu-Lin Jiang, Peng-Fei Cui, Rong-Lin Xie, Chong-Su Cho
https://www.researchgate.net/publication/43051525_Chemical_modification_of_siRNA
Chemical modification of siRNA. ... efficient delivery to target cells and tissues have significantly limited the biomedical applications of siRNA. However, chemical modification is a powerful ...
https://www.ncbi.nlm.nih.gov/pubmed/24730283
Chemical modification of chitosan with pH-sensitive molecules and specific ligands for efficient DNA transfection and siRNA silencing. Singh B, Choi YJ, Park IK, Akaike T, Cho CS. Successful gene therapy depends on the development of efficient and cell-specific gene delivery systems.Author: Bijay Singh, Yun-Jaie Choi, In-Kyu Park, Toshihiro Akaike, Chong-Su Cho
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835214/
Jun 30, 2009 · Instability and inadequate biodistribution of double-stranded RNA are major drawbacks to the clinical use of RNA interference. This work compares chemical modification and nanoparticle formulation as strategies to improve the systemic delivery of small interfering RNA (siRNA).Author: Shan Gao, Frederik Dagnaes-Hansen, Ebbe Juel Bech Nielsen, Jesper Wengel, Flemming Besenbacher, Kenn...
http://cdn.intechopen.com/pdfs/21832/InTech-Chitosan_dna_sirna_nanoparticles_for_gene_therapy.pdf
Chitosan-DNA/siRNA Nanoparticles for Gene Therapy 457 be unsatisfactory. Research efforts to improve the in vivo DNA-delivery efficacy of non-viral vectors are ongoing. 2.3 Barriers to DNA delivery Systemic gene delivery involves a systemic approach in which exogenous genes are
https://pubs.acs.org/doi/abs/10.1021/bc1000609
Chitosan has the potential to be a biocompatible gene carrier. However, the transfection efficiency of chitosan is low because of the slow endosomal escape rate. The buffering capacity of histidine in the endosomal pH range would help the escape of plasmid DNA (pDNA) from endosomes. In this study, histidine was introduced into chitosan to improve the transfection efficiency.Author: Kai-Ling Chang, Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
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