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https://www.future-science.com/doi/full/10.4155/tde-2017-0037
Jul 21, 2017 · Pulmonary drug delivery is relatively complex because the respiratory tract has evolved defense mechanisms to keep inhaled drug particles out of the lungs and to remove or inactivate them once deposited. In addition to these mechanical, chemical and immunological barriers,...Author: Stephen P Newman
https://erj.ersjournals.com/content/44/3/765
Sep 01, 2014 · In asthma, for example, drug delivery to the upper airways is needed while for alveolar lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis, it is important to have drug deposition in the deep lung rather than the upper airways.Author: Sabine H. van Rijt, Thomas Bein, Silke Meiners
https://www.crcpress.com/Drug-Delivery-to-the-Lung/Bisgaard-OCallaghan-Smaldone/p/book/9780367396879
Giving the clinician an overview of factors essential to understanding drug delivery via nebulization, Drug Delivery to the Lung is a superlative reference for pulmonologists; physiologists; pharmaceutical scientists; immunologists; allergists; analytical, organic, and medicinal chemists and biochemists; chemical, genetic, and process engineers; and medical and graduate school students in these …
https://erj.ersjournals.com/content/erj/44/3/765.full.pdf
In asthma, for example, drug delivery to the upper airways is needed while for alveolar lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis, it is important to have drug deposition in the deep lung rather than the upper airways.Author: Sabine H. van Rijt, Thomas Bein, Silke Meiners
http://www.pharmtech.com/four-challenges-pulmonary-drug-delivery
Sep 01, 2017 · The delivery of therapeutic agents as aerosols using metered dose (MDIs) or dry powder inhalers (DPIs) can be very effective for administering drugs locally to, or systemically through, the lungs. A key challenge, however, is to generate drug particles of a suitable size range.
https://aerosol-soc.com/events/ddl2019/
The Drug Delivery to the Lungs (DDL) Conference provides an annual forum for scientists, academics, clinicians, regulatory and industry specialists involved in developing medicines for inhalation. DDL2019 will have five themed sessions each with a combination of invited and submitted lectures given by experts in the field of inhalation and students working to advance respiratory science. Alongside the lecture …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039485/
Traditional pharmacotherapy for chronic lung diseases can be classified into a few categories according to types of therapeutic agents. A variety of chemical drugs, peptides, antibodies, and genetic molecules (e.g., siRNA, shRNA, and miRNA) have been employed to treat the chronic lung diseases …Author: Ji Young Yhee, Jintaek Im, Richard Seonghun Nho
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276033/
In the intratracheal instillation, a small amount of drug solution or dispersion is delivered into the lungs by a special syringe. This provides a fast and quantifiable method of drug delivery to the lungs. The localized drug deposition is achieved with a comparatively small absorptive area.
https://www.atsjournals.org/doi/full/10.1513/pats.200409-049TA
Dec 01, 2004 · The lungs are even more permeable to small molecules than the gastrointestinal (GI) tract (2). In contrast to oral delivery, where a drug can be heavily metabolized and altered by the enzymes of the gut and liver, the lungs have only a small fraction of the drug-metabolizing and efflux transporter activity of the gut and liver (3 – 5).Author: John S. Patton, C. Simone Fishburn, Jeffry G. Weers
https://pubs.acs.org/doi/10.1021/acs.biomac.7b01356
Chemical structures of functional polyesters modified with amino- and alkyl-thiols used in the study, cell viability after treatment with mRNA polyplex NPs, effects of PEG2000 DMG lipid on mRNA delivery, and ex vivo quantification of luminescence intensity in organs after administration of mRNA polyplex NPsAuthor: Yunfeng Yan, Yunfeng Yan, Hu Xiong, Xinyi Zhang, Qiang Cheng, Daniel John Siegwart
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