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https://onlinelibrary.wiley.com/doi/10.1002/0471475734.ch2
Mar 11, 2005 · Summary This chapter contains sections titled: Introduction Physiological Barriers to Drug Delivery Biochemical Barriers to Drug Delivery Chemical …Author: Anna Maria Calcagno, Teruna J. Siahaan
https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781118833322.ch2
Mar 25, 2016 · Oral delivery of small and large molecules has been the focus of many review articles. This chapter focuses on various aspects of the intestinal mucosa barrier and potential solutions to overcome these barriers. The properties of the intestinal mucosa barrier and types of molecules that can penetrate the barrier are discussed in detail.Author: Anna Maria Calcagno, Teruna J. Siahaan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978509/
Framework of sequential biological barriers to nanoparticle drug delivery. Upon intravenous administration, drug-containing nanoparticles encounter a number of sequential obstacles hindering efficacious, site-specific delivery to tumors. Nanoparticles undergo opsonization and subsequent uptake by resident macrophages of the MPS.Author: Elvin Blanco, Haifa Shen, Haifa Shen, Mauro Ferrari, Mauro Ferrari
https://www.slideshare.net/PrachiJoshi8/barriers-encountered-in-drug-delivery
Jan 26, 2015 · The drug can pass either between or through the cells, depending on its physicochemical properties. Overcoming these barriers help in the development of improved drug delivery systems to treat different diseases conditions. Although many challenges exist in transporting the drug from different barriers, that’s why pharmaceutical scientists ...
https://www.researchgate.net/publication/319195506_Chitosan_and_its_Derivatives_as_Chemical_Drug_Delivery_Carriers
Chitosan and its Derivatives as Chemical Drug Delivery Carriers. ... [Show full abstract] act as natural barriers to isolate cellular contents from the external environment. In addition, various ...
https://www.researchgate.net/publication/312523618_Physiological_Biochemical_and_Chemical_Barriers_to_Oral_Drug_Delivery_Principles_and_Applications
Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery: Principles and Applications. ... T o enhance drug delivery to cross these various barriers, many of these f actors can be .
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106925/
Jul 22, 2014 · In order to arrive at the appropriate solutions we must first seek to identify and understand the problems. The complexity of the in vivo system thus inflicts multiple biological barriers which impedes NP drug delivery to solid tumors. 2 In current anti-cancer therapies, NPs are generally administered intravenously (IV). This route is fast ...Author: Shravan Kumar Sriraman, Bhawani Aryasomayajula, Vladimir P Torchilin
https://pubs.acs.org/doi/abs/10.1021/acs.accounts.9b00177
The application of such devices in drug delivery has proven to be beneficial for matters as diverse as drug solubility, drug targeting, controlled drug release, and transport of drugs across cellular barriers.Author: Isabelle M S Degors, Cuifeng Wang, Zia Ur Rehman, Inge S Zuhorn
https://www.sciencedirect.com/science/article/pii/S1748013219302786
Encouragingly, these barriers that impede the efficacy of anti-PD therapy can be potentially addressed by nanosized drug delivery systems (NDDS) [37,38].NDDS can reduce the “on target but off tumor” effect of anti-PD drugs by delivering them specifically into tumors, taking advantages of their passive or active targeting capability after proper modification and engineeringAuthor: Xiaochen Liu, Dangge Wang, Pengcheng Zhang, Yaping Li, Yaping Li
https://www.sciencedirect.com/science/article/pii/S0168365919303153
The current limitations in the use of nanocarriers to treat constantly evolving diseases call for the design of novel and smarter drug delivery systems (DDS). Nanogels (NGs) are three-dimensional crosslinked polymers with dimensions on the nanoscale and with a great potential for use in the biomedical field.Author: Julio César Cuggino, Julio César Cuggino, Ernesto Rafael Osorio Blanco, Ernesto Rafael Osorio Blanco...
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