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https://www.ncbi.nlm.nih.gov/pubmed/29431061
However, there are several challenges in developing an oral route for insulin delivery; insulin has extremely poor bioavailability and a low diffusion rate through the mucus layer. A wide range of oral insulin delivery techniques have recently been researched, ranging from nanoparticles to liposomes, self-emulsifying systems, and hydrogels.Author: Dinesh Kumar Chellappan, Yap Yenese, Chew Chian Wei, Jestin Chellian, Gaurav Gupta
https://www.onlinelibrary.wiley.com/doi/full/10.1111/jphp.12852
Nov 28, 2017 · Challenges in oral delivery of insulin. The fundamental barrier to the oral delivery of proteins is the gastrointestinal tract (GIT). The GIT functions as an absorptive and protective organ. Active macromolecules have to undergo degradation into inactive components before they face the next absorption barrier, the tight epithelium.Author: Ahmed Gedawy, Jorge Martinez, Hani Al‐Salami, Crispin R. Dass
https://www.sciencedirect.com/book/9781907568473/oral-delivery-of-insulin
Abstract. One of the greater challenges faced by oral delivery of insulin is the reduced bioavailability. Among the different types of carrier-based delivery systems currently being pursued for oral insulin delivery, biodegradable polymeric nanoparticles have received considerable attention due to their versatility and wide range of properties.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · Oral insulin delivery has been an interesting and promising research field that promises to revolutionize the way diabetes mellitus is treated. Several studies have achieved some positive results, and some delivery systems are in advanced stages of development.Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jphp.12607
tions, so other forms of delivery are being tested, including oral administration. This review summarises the developments in oral insulin administration. Methods The PubMed database was consulted to compile this review comparing conventional subcutaneous injection of insulin to the desired oral delivery.Author: Chun Y. Wong, Jorge Martinez, Crispin R. Dass
https://www.sciencedirect.com/science/article/pii/B978032347720800016X
This chapter presents an overview of diabetes highlighting various aspects of insulin therapy, including insulin analogs, oral delivery of insulin, mechanistic action of insulin, challenges of oral administration of insulin and breakthroughs in insulin delivery at the global level.Author: Raje Chouhan, Shilpi Goswami, Anil Kumar Bajpai
https://www.researchgate.net/publication/288498357_Oral_insulin_delivery_-_challenges_and_strategies
Integrating the strategies based on the complexation hydrogels and insulin-transferrin conjugates may prove to be a novel approach for oral delivery of insulin and other therapeutic proteins.
https://www.researchgate.net/publication/304706250_Oral_delivery_of_insulin_for_treatment_of_diabetes_status_quo_challenges_and_opportunities
Oral delivery of insulin for treatment of diabetes: status quo, challenges and opportunities Article · Literature Review · June 2016 with 69 Reads How we measure 'reads'
https://www.elsevier.com/books/oral-delivery-of-insulin/sonia/978-1-907568-47-3
Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin.
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