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https://www.nature.com/articles/nrd1067
Apr 01, 2003 · Challenges for the oral delivery of macromolecules Abstract. The rapid integration of new technologies by the pharmaceutical industry has resulted in... Key Points. Macromolecules comprise a growing group of new pharmaceutical products with... References. Brange, J. …Author: Michael Goldberg, Isabel Gomez-Orellana
https://www.ncbi.nlm.nih.gov/pubmed/12669028
Challenges for the oral delivery of macromolecules. Goldberg M(1), Gomez-Orellana I. Author information: (1)Emisphere Technologies Inc, 765 Old Saw Mill River Road Tarrytown, New York 10591, USA. [email protected]: Michael Goldberg, Isabel Gomez-Orellana
https://www.researchgate.net/publication/10827892_Challenges_for_the_oral_delivery_of_macromolecules
Challenges for the oral delivery of macromolecules Article · Literature Review in Nature Reviews Drug Discovery 2(4):289-95 · May 2003 with 144 Reads How we measure 'reads'
https://www.westpharma.com/blog/2019/May/delivering-macromolecules-challenges-associated-with-delivery-biologics
May 16, 2019 · Delivering Macromolecules: Challenges Associated with the Delivery of Biologic Drugs Biologic drugs, rather than being synthesized from other compounds, are generally made using human or animal proteins. At the molecular level, they’re usually larger …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410172/
Feb 13, 2019 · Challenges for Oral Delivery of Macromolecules Oral administration of hydrophilic macromolecules with a molecular weight (MW) above 1000 Da remains a challenge due to susceptibility to pH and gastric/small intestinal enzymes, as well as low intestinal epithelial membrane permeability.Author: Caroline Twarog, Sarinj Fattah, Joanne Heade, Sam Maher, Elias Fattal, David J. Brayden
https://link.springer.com/article/10.1007/s12257-009-3058-4
Mar 18, 2010 · Oral delivery technologies including carrier systems, absorption enhancers, protease inhibitors, and modification by conjugating transporter or receptor recognition molecules have been developed and some are undergoing clinical studies.Author: Jin Woo Park, Sang Kyoon Kim, Taslim Ahmed Al-Hilal, Ok Cheol Jeon, Hyun Tae Moon, Youngro Byun
http://www.pharmtech.com/oral-delivery-macromolecular-drugs
Jul 02, 2018 · Oral delivery of macromolecule drugs Being able to deliver macromolecular IBD treatments orally would improve patient experience, avoid systemic exposure, and increase drug presence at disease sites. However, maintaining stability and activity in the GI is a significant challenge.
https://science.sciencemag.org/content/363/6427/611.full
Feb 08, 2019 · Motivated by patient and health care professional preference for oral delivery, research on ingestible biomacromolecule formulations began in 1922, the same year as the first insulin injection ( 1, 2 ). This initial study, along with others that followed, was …Author: Alex Abramson, Ester Caffarel-Salvador, Minsoo Khang, David Dellal, David Silverstein, Yuan Gao, Mor...
http://www.pharmtech.com/oral-delivery-biologic-apis-challenge-continues
Mar 02, 2017 · The greatest challenge to the oral delivery of biologic APIs is absorption across the GI tract, according to Ronak Savla, scientific affairs manager, Catalent Pharma Solutions. Most oral drugs are absorbed in the small intestine, which has the highest permeability compared to the large intestine and stomach.
https://www.future-science.com/doi/10.4155/tde.11.128
Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies. ... Gomez-Orellana I. Challenges for the oral delivery of macromolecules. Nat. Rev. ... Oral delivery of macromolecules: highlighting the challenges to maximize opportunities.Author: BT Griffin, CM O’Driscoll
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