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https://pubs.acs.org/doi/abs/10.1021/bk-2009-1017.ch004
Dec 20, 2009 · To test whether cellulose nanocrystals could be used as carriers in the targeted delivery of therapeutics, their toxicity to human brain microvascular endothelial cells was measured. Cellulose nanocrystals were found to be non-toxic to the cells. For cellular uptake studies, cellulose nanocrystals were labeled with fluorescein-5'-isothiocyanate.
https://www.researchgate.net/publication/279403770_Cellulose_Nanocrystals_for_Drug_Delivery
The current study is aimed at introducing cellulose nanocrystals as suitable carriers for drug delivery to skin. Prepared cellulose nanocrystals were characterized by dynamic light scattering and atomic force microscopy. The size of cellulose nanocrystals determined using dynamic light scattering was 301±10 nm.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044185/
Feb 10, 2011 · Using an acid hydrolysis method, cellulose crystallites, or what we termed NCC crystallites, were isolated and investigated for use as a drug delivery excipient. The XRPD pattern, which is characterized by two high intensity peaks, indicates the high degree of crystallinity of the material (Figure 1).Author: John K Jackson, Kevin Letchford, Benjamin Z Wasserman, Lucy Ye, Wadood Y Hamad, Helen M Burt
https://www.pharmaexcipients.com/news/cellulose-nanocrystal-membranes-as-excipients-for-drug-delivery-systems/
Dec 19, 2016 · In this work, cellulose nanocrystals (CNCs) were obtained from flax fibers by an acid hydrolysis assisted by sonochemistry in order to reduce reaction times. The cavitation inducted during hydrolysis resulted in CNC with uniform shapes, and thus …
https://www.mdpi.com/2079-4991/8/4/228/htm
Spherical cellulose nanocrystal-based hybrids grafted with titania nanoparticles were successfully produced for topical drug delivery. The conventional analytical filter paper was used as a precursor material for cellulose nanocrystals (CNC) production.Author: Olga L. Evdokimova, Fredric G. Svensson, Alexander V. Agafonov, Sebastian Håkansson, Gulaim A. Seise...
https://pubag.nal.usda.gov/catalog/6783641
The incorporation of the nanocrystals modified the internal porous microstructure of the hydrogels, affecting consequently both the swelling capacity and the drug-delivery kinetics. Moreover, the prepared nanocomposite hydrogels showed non-toxic behavior, demonstrating their potential applicability in the biomedical field, especially as ...
https://www.sciencedirect.com/science/article/pii/S0378517317309304
In order to develop drug delivery systems with desirable properties, especially for problematic drugs, the use and development of new excipients (and formulation approaches) is often necessary. One promising excipient in this regard is cellulose nanofibers (CNFs).Author: Korbinian Löbmann, Anna J. Svagan
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