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https://www.frontiersin.org/articles/10.3389/fcimb.2013.00013/full
Nanoparticles as Vaccine Delivery Vehicles. Traditional vaccines include live attenuated microbes, killed microbes, or components of microbes. Although many of these vaccines have been central to the control of infectious disease, some do not afford good protection against disease.Author: Anthony E. Gregory, Richard Titball, Diane Williamson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024302/
A convenient DNA vaccine delivery system is oral vaccination using live-attenuated Salmonella typhimurium. The use of attenuated Salmonella strains as vehicles to deliver plasmid DNA in vivo indicated an effective method to induce strong cell-mediated and humoral immune responses at …Author: Azam Bolhassani, Shima Safaiyan, Sima Rafati
https://www.ncbi.nlm.nih.gov/pubmed/28669593
Sep 10, 2017 · The majority of existing vaccine adjuvants lack the ability to significantly stimulate the cellular immune response, which is required to prevent the aforementioned diseases. This study designed a novel particulate based pathogen-mimicking vaccine delivery system (PMVDS) to target antigen-presenting-cells (APCs) such as dendritic cells.Author: Sunny Kumar, Siddharth S. Kesharwani, Bhimanna Kuppast, Mohammed Ali Bakkari, Hemachand Tummala
https://www.hindawi.com/journals/jir/2019/8303648/
Additionally, the capability of this system to perform posttranslational modifications, the GRAS status, and the cellular wall that could protect the antigen across the GIT make engineered yeasts an attractive vaccine delivery system [23, 65].Author: E. Criscuolo, V. Caputo, V. Caputo, R. A. Diotti, R. A. Diotti, G. A. Sautto, G. A. Kirchenbaum, N. ...
https://www.sciencedirect.com/science/article/pii/S016836591930118X
An ideal vaccine delivery system should activate effectively CD8 + as well as CD4 + T cells. CD4 + T then differentiates into subsets of helper T cells such as Th1 and Th2 cells . Th1 and Th2 cell subsets are known to promote the activation of CTLs or B cells by producing antibodies .Author: Xiaofang Zhong, Yunting Zhang, Lu Tan, Tao Zheng, Yingying Hou, Xiaoyu Hong, Guangsheng Du, Xiaoyan ...
https://www.mdpi.com/2076-393X/5/4/41
(1) Background: Cytoplasmic delivery of antigens is crucial for the induction of cellular immunity, which is an important immune response for the treatment of cancer and infectious diseases. To date, fusogenic protein-incorporated liposomes and pH-responsive polymer-modified liposomes have been used to achieve cytoplasmic delivery of antigen via membrane rupture or fusion with endosomes ...Author: Eiji Yuba, Naoki Sakaguchi, Yuhei Kanda, Maiko Miyazaki, Kazunori Koiwai
https://academic.oup.com/bmb/article/62/1/29/281120
Jul 01, 2002 · Abstract. There is currently intense research activity aimed at the development of new delivery systems for vaccines. The goal is to identify optimal methods for presenting target antigens to the immune system in a manner that will elicit immune responses appropriate for protection against, or treatment of, a specific disease.Author: Philippe Moingeon, Charles de Taisne, Jeffrey Almond
https://www.sciencedirect.com/science/article/pii/S0264410X20303297
In this study, we identified eosinophils as the cellular target of DNA delivery from orally administrated L. lactis carrying a eukaryotic expression plasmid. In the future study, we need to investigate whether this DNA delivery system leads to induction of the antigen-specific immune responses, including humoral and cell-mediated immunity.Author: Keita Takahashi, Nozomi Orito, Daiki Yanagisawa, Ayumu Yano, Yusuke Mori, Naoki Inoue
https://www.researchgate.net/publication/270002235_Lipid-based_mRNA_vaccine_delivery_systems
Lipid-based mRNA vaccine delivery systems. ... lymphoid organs via the lymphatic system, ... cellular delivery of cargo. Thus, a compromise should be foun d.
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