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https://www.sciencedirect.com/science/article/pii/S1359644604032799
Applications of cell-penetrating peptides Intracellular delivery. The ability to deliver large hydrophilic molecules, such as peptides, proteins, nucleic acids and large particles, into cells is a significant challenge because of the bioavailability restriction imposed by the cell membrane.Author: Jamal Temsamani, Pierre Vidal
https://www.sciencedirect.com/science/article/pii/S0304419X08000176
1. Cell-penetrating peptides (CPPs) The efficient passage of drugs through the plasma membrane remains a major hurdle for drug delivery. Good cell uptake often requires the administration of high quantities of drugs in order to obtain the expected intracellular biological effect.Author: Eric Vivès, Julien Schmidt, André Pèlegrin
https://link.springer.com/article/10.1023/B:PHAM.0000019289.61978.f5
Mar 01, 2004 · Protein transduction domains (PTDs) are small cationic peptides that can facilitate the uptake of large, biologically active molecules into mammalian cells. Recent reports have suggested that PTDs may be able to mediate the delivery of cargo to tissues throughout a living organism. Such technology could eliminate the size restrictions on usable drugs, enabling previously unavailable large ...Author: Eric L. Snyder, Steven F. Dowdy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492185/
Apr 22, 2015 · Introduction: The impermeability of biological membranes is a major obstacle in drug delivery; however, some peptides have transition capabilities of biomembranes. In recent decades, cell-penetrating peptides (CPPs) have been introduced as novel biocarriers that …Author: Samira Jafari, Solmaz Maleki Dizaj, Khosro Adibkia
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(17)30017-2
The presence of cell and tissue barriers together with the low biomembrane permeability of various therapeutics often hampers systemic drug distribution; thus, most of the available molecules are of limited therapeutic value. Opportunities to increase medicament concentrations in areas that are difficult to access now exist with the advent of cell-penetrating peptides (CPPs), which can ...Author: Giulia Guidotti, Liliana Brambilla, Daniela Rossi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030843/
Mar 30, 2012 · Cell penetrating peptides therefore are used to promote the delivery of associated drugs and drug carriers into cells. Despite the fact that the exact mechanisms underlying the internalization of CPPs across the cellular membrane are not fully understood, a large number of different therapeutic agents have been efficiently delivered by CPPs.Author: Were Ll Munyendo, Huixia Lv, Habiba Benza-Ingoula, Lilechi D. Baraza, Jianping Zhou
https://www.cell.com/trends/molecular-medicine/pdf/S1471-4914(15)00122-7.pdf
combines the cell-penetrating capacity of CPPs with the ability of homing peptides (most of which are inherently cell impermeable), to recognize specific cell types. By conjugating the homing domains to CPPs (to effect translocation across the cell membrane), the speci-ficity of CPP-based drug delivery systems has been in-creased [32].File Size: 872KB
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