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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391616/
Mar 26, 2015 · 1.1. Cell-Penetrating Peptides. The plasma membrane plays essential roles in selective permeability, osmotic balance, compartmentalization, and cellular uptake. Small polar molecules such as ions, amino acids, and sugars enter cells through …Author: Yue-Wern Huang, Han-Jung Lee, Larry M. Tolliver, Robert S. Aronstam
https://www.tandfonline.com/doi/abs/10.1517/17425247.2012.689285
May 04, 2017 · Among non-viral vectors, cell-penetrating peptides (CPPs) have been extensively used for the delivery of nucleic acids both in vitro and in vivo.Author: Taavi Lehto, Kaido Kurrikoff, Ülo Langel
https://www.nature.com/articles/srep17640
Nov 27, 2015 · Delivery of cell-penetrating peptide-peptide nucleic acid conjugates by assembly on an oligonucleotide scaffold Scientific Reports Delivery to intracellular target sites is …Author: Xing-Liang Zhao, Bi-Cheng Chen, Jin-Chao Han, Lai Wei, Xiao-Ben Pan
https://www.researchgate.net/publication/224976554_Cell-penetrating_peptides_for_the_delivery_of_nucleic_acids
Among non-viral vectors, cell-penetrating peptides (CPPs) have been extensively used for the delivery of nucleic acids both in vitro and in vivo.
https://pubs.acs.org/doi/10.1021/bc9000454
The cell-penetrating peptide D-Tat57−49 was selected over two other derivatives of HIV-1 Tat peptide, based on its superior intracellular delivery of the gadolinium-based contrast agents. Further improved delivery of conjugates was achieved upon coupling peptide nucleic acids (antisense to mRNA of DsRed2 protein and nonsense with no natural counterpart).Author: Ritu Mishra, Wu Su, Rolf Pohmann, Josef Pfeuffer, Josef Pfeuffer, Martin G. Sauer, Kamil Ugurbil, Jö...
https://www.sciencedirect.com/science/article/pii/B9780128136652000028
Cell-penetrating peptides (CPPs) have the ability to pass biological membranes and enter cells. Due to this intrinsic property, CPPs are employed as vectors for intracellular delivery of nucleic acids and nanoparticles. In this chapter, we first briefly describe the classification and uptake mechanisms of CPPs.Author: Canan Ozyurt, Ozge Ugurlu, Serap Evran
https://pubs.acs.org/doi/10.1021/acsbiomaterials.8b00180
In the delivery of cell-impermeable molecules, cell-penetrating peptides (CPPs) have been attracting increasing attention as intracellular delivery tools. In the present study, we designed four types of cyclic α,α-disubstituted α-amino acids (dAAs) with basic functional groups on their five-membered rings and different chiralities at the α-position and introduced them into arginine (Arg ...Author: Takuma Kato, Takuma Kato, Makoto Oba, Koyo Nishida, Masakazu Tanaka
https://www.mdpi.com/1422-0067/21/7/2536/pdf
peptides, proteins, nucleic acids, or particles. In spite of this, it was not the intention of this review to exhaustively summarize all facets of CPP research, but more to highlight the main key facts about their
https://www.nature.com/articles/s41598-018-38063-8
Here, we prepared four types of L-arginine-rich nonapeptides containing L-leucine or α,α-disubstituted α-amino acids, and evaluated their secondary structures and cell-penetrating abilities in ...Author: Makoto Oba, Yu Nagano, Takuma Kato, Takuma Kato, Masakazu Tanaka
http://health120years.com/cn/pdf/db_VD_Ebola_CPP-PMOs_Intracellular-Delivery.pdf
oligomers (PMO, Figure 1) (1) and peptide nucleic acids (PNAs) (2). Conjugation of PMO to short CPPs is a good method to enhance the cytoplasmic and nuclear delivery of PMO because the conjugates are simple to use and because the short peptides and their AO conjugates can be easily manufactured and characterized in a quality-controlled manner.Author: Rebecca P. Wu, Derek S. Youngblood, Jed N. Hassinger, Candace E. Lovejoy, Michelle H. Nelson, Patric...
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