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https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are …
https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201901489
Cell‐specific drug delivery remains a major unmet challenge for cancer nanomedicines. Here, light‐triggered, cell‐specific delivery of liposome‐encapsulated doxorubicin to xenograft human cancer cells in live zebrafish embryos is demonstrated.Author: Li Kong, Quanchi Chen, Frederick Campbell, Ewa Snaar‐Jagalska, Alexander Kros
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062753/
Safety of cell-mediated drug delivery systems . An obvious concern for inflammatory-response cell based drug delivery relates to possible cytotoxic effects of cell-carriers. MP attracted to the site of pathology by cytokines release reactive oxygen species (ROS) that cause cell damage.Author: Elena V. Batrakova, Howard Eliot Gendelman, Alexander V. Kabanov
https://www.sciencedirect.com/science/article/pii/S0169409X07002505
Drug delivery has been greatly improved over the years by means of chemical and physical agents that increase bioavailability, improve pharmacokinetic and reduce toxicities. At the same time, cell based delivery systems have also been developed.Author: F. Pierigè, S. Serafini, L. Rossi, M. Magnani
https://www.cell.com/matter/fulltext/S2590-2385(19)30165-1
Adipocytes were engineered for local delivery of anticancer therapeutics, including fatty acid and small-molecule drug. The lipolysis triggered by tumor cells promoted the release of these anticancer therapeutics. In addition, the immunogenic tumor phenotype induced by anticancer fatty acid combined with tumor-responsive doxorubicin prodrug enhanced cancer therapy.Author: Di Wen, Di Wen, Jinqiang Wang, Jinqiang Wang, George Van Den Driessche, Qian Chen, Qian Chen, Yuqi Z...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
The non restricted (cyto)toxicity of chemotherapeutics thus limits the full use of their therapeutic potential. Local drug delivery or drug targeting results in increased local drug concentrations and provides strategies for more specific therapy. Nanoparticles have specific particles as …Author: Wim H De Jong, Paul Ja Borm
https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · RNA delivery for disease treatment often has low uptake efficiencies and cytotoxicity. Here the authors produce extracellular vesicles from red blood cells for in vivo cargo delivery.Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://advances.sciencemag.org/content/5/10/eaaw6870.full
Oct 01, 2019 · Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery platform due to their inherent biocompatibility. Here, we developed an antigen delivery system based on the nanoerythrosomes derived from RBCs, inspired by the splenic antigen-presenting cell targeting capacity of senescent RBCs. Tumor antigens were loaded onto the nanoerythrosomes by fusing …Author: Xiao Han, Shufang Shen, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu, Zhen G...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-delivery-vehicle
G BARRATT, in Artificial Cells, Cell Engineering and Therapy, 2007. 3.5 Future trends. Colloidal drug delivery vehicles have been studied in the laboratory for more than 30 years, but the few liposome-based formulations already on the market are mainly concerned with reducing the side effects of the encapsulated drugs. Now that the interactions between particles and biological milieux are ...
https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1860-7187.hottopic-drugdelivery
Mar 21, 2020 · The importance of drug delivery to chemists, medicinal and otherwise, has increased since the advent of integrated drug discovery processes. Physicochemical and biological barriers, pathways for drug delivery, formulation, pharmacokinetic and pharmacodynamic issues, metabolism, and cell culture models used in studying drug delivery are just some of the topics that make drug delivery …
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