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https://www.sciencedirect.com/science/article/pii/B9780124160200000140
Cell delivery of drug nanoparticles has been demonstrated for animal models of disease. However, these methods have not yet been tested in a clinical setting. For clinical use, cell carriers could be harvested from the patient's blood by apharesis, loaded with drug, and then readministered to the patient.Author: JoEllyn M McMillan, Elena Batrakova, Howard Eliot Gendelman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016803/
Cell Delivery of Therapeutic Nanoparticles. ... Cell delivery of drug nanoparticles has been demonstrated for animal models of disease. However, these methods have not yet been tested in a clinical setting. For clinical use, cell carriers could be harvested from the patient’s blood by apharesis, loaded with drug, and then readministered to ...Author: JoEllyn M McMillan, Elena Batrakova, Howard Eliot Gendelman
https://www.ncbi.nlm.nih.gov/pubmed/22093229
Cell delivery of therapeutic nanoparticles. McMillan J(1), Batrakova E, Gendelman HE. Author information: (1)Department of Pharmacology and Experimental Neuroscience, Nebraska Medical Center, Omaha, NE, USA.Author: JoEllyn M McMillan, Elena Batrakova, Howard Eliot Gendelman
https://www.researchgate.net/publication/51810001_Cell_Delivery_of_Therapeutic_Nanoparticles
Cell Delivery of Therapeutic Nanoparticles. ... As reported in several review articles, cell-mediated drug delivery has emerged to overcome these obstacles and to serve as an alternative for the ...
http://pubs.acs.org/doi/abs/10.1021/nl072209h
Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as “Trojan Horses” for nanoparticle transport into these tumor regions.
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(19)30538-6
Nov 26, 2019 · In addition to cell-cell crosslinking induced by αCD3-αHER2 SMART-Exos, confocal microscopic analysis revealed cellular uptake of the PKH67-labeled αCD3-αHER2 SMART-Exos by both Jurkat and HCC 1954 cells . These data demonstrate cell-cell interactions induced by αCD3-αHER2 SMART-Exos and suggest possible therapeutic cargo delivery by ...Author: Xiaojing Shi, Qinqin Cheng, Tianling Hou, Menglu Han, Goar Smbatyan, Julie E. Lang, Alan L. Epstein,...
https://pubs.acs.org/doi/10.1021/acsnano.5b05583
Oct 30, 2015 · Endothelial cells form a monolayer in lumen of blood vessels presenting a great barrier for delivery of therapeutic nanoparticles (NPs) into extravascular tissues where most diseases occur, such as inflammation disorders and infection. Here, we report a strategy for delivering therapeutic NPs across this blood vessel barrier by nanoparticle in situ hitchhiking activated neutrophils. Using ...Author: Dafeng Chu, Jin Gao, Zhenjia Wang
https://advances.sciencemag.org/content/6/3/eaax3931.full
Jan 01, 2020 · We have developed a therapeutic nanoparticle formulation approach that balances cell surface receptor-specific binding affinity while maintaining minimal interactions with blood and tumor tissue components (termed “DART” nanoparticles), thereby improving blood circulation time, biodistribution, and tumor cell–specific uptake.Author: Jimena G. Dancy, Aniket S. Wadajkar, Nina P. Connolly, Rebeca Galisteo, Heather M. Ames, Sen Peng, N...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)38877-3
May 01, 2009 · In summary, we have found that compacted DNA nanoparticles are able to effectively deliver nucleic acid to the mouse brain. The long-term expression from the DNA delivered by the nanoparticles suggests that a single bolus administration of a nucleic acid therapy may provide adequate levels of therapeutic molecule expression for many months.
https://www.sciencedirect.com/science/article/pii/S0168365914002168
These highlighted cells have been used for therapeutic functions, and recent works are investigating the potential these cells have for either improved delivery of therapeutic nanoparticles or utilizing nanoparticles that improve the natural therapeutic function of the cell itself.Author: Aaron C. Anselmo, Samir Mitragotri
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