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https://www.sciencedirect.com/topics/materials-science/cationic-polymer
Cationic polymers that have shown significant promise as gene delivery agents are more effective than the state-of-the art, commercially available non-viral systems. Gene delivery in vivo involves interactions with the biophase (the effect site of drug) prior to reaching the target cells which complicates efforts to understand the mechanism of ...
https://www.researchgate.net/publication/281728954_Cationic_polymers_in_drug_delivery
Cationic Polymers in Drug Delivery 299 rifampin, an anionic antibiotic used to treat tubercu losis and meningitis, and chitosan was obtained in the form of a film to provide co ntrolled de-
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
In 1987, Felgner et al. used the cationic lipid based non-viral gene delivery system for the very first time. This breakthrough opened the opportunity for other non-viral vectors, such as polymers. Cationic polymers have emerged as promising candidates for non-viral gene delivery systems because of their facile synthesis and flexible properties.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Having pH-sensitivity, cationic polymers can mask the taste of drugs and release drugs in the stomach by responding to gastric low pH. Anionic polymers responsive to intestinal high pH are used for preventing gastric degradation of drug, colon drug delivery and achieving high bioavailability of weak basic drugs.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://www.ncbi.nlm.nih.gov/pubmed/29103306
Cationic polymers have been employed commonly as drug delivery agents due to their superior encapsulation efficacy, enhanced bioavailability, low toxicity and improved release profile. In this paper, we focus on the most prominent examples of cationic polymers which have been revealed to be applicable in drug delivery systems and we also ...
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://pubs.rsc.org/en/content/articlelanding/2012/cs/c2cs35094g
Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various ...Author: Sangram Keshari Samal, Mamoni Dash, Sandra Van Vlierberghe, David L. Kaplan, Emo Chiellini, Clemens ...
http://www.freepatentsonline.com/y2018/0318231.html
Nov 08, 2018 · Cationic polymers are provided for drug delivery. The cationic polymers can be used for delivering anionic active agents, preferably in the form of nanoparticles and other nanostructures. In some embodiments the nanoparticles and nanostructures have high loading efficiencies, even for anionic active agents such as nucleic acids and negatively ...Author: Omid Farokhzad, Jun Wu, Lili Zhao
https://www.researchgate.net/publication/320903054_Significant_role_of_cationic_polymers_in_drug_delivery_systems
Cationic polymers have been employed commonly as drug delivery agents due to their superior encapsulation efficacy, enhanced bioavailability, low toxicity and improved release profile.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/cationic-surfactants
Most importantly, cationic amphiphiles improve the loading capacity of drug delivery systems (liposomes, hydrogels, lipid particles) for a variety of drugs and even improve the drug solubility by complexing it with self-assembled colloidal aggregates, micelles, or vesicles (Severino et al., 2015; Fangueiro et al., 2016).
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