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https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://www.sciencedirect.com/science/article/pii/S0168365918301202
Polymers for gene delivery are typically made of cationic monomers that contain primary, secondary, and/or tertiary amine groups that can complex with negatively charged nucleic acid to form condensed polymer-nucleic acid nanoparticle complexes, called “polyplexes” .Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
In 1987, Felgner et al. used the cationic lipid based non-viral gene delivery system for the very first time. This breakthrough opened the opportunity for other non-viral vectors, such as polymers. Cationic polymers have emerged as promising candidates for non-viral gene delivery systems because of their facile synthesis and flexible properties.
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · The use of cationic lipids for gene delivery was first reported by Felgner in 1987 24.The lipid structures affect the interactions of the lipids with DNA and influence the membrane properties of ...Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294582/
Polymers are synthetic gene delivery vectors which possess the ability to deliver genetic material to target cells [3, 4, 12, 13]. Cationic polymers neutralize the negative charge on plasmid DNA resulting in the formation of nanoscale polymer-DNA complexes (polyplexes).Author: Sutapa Barua, James Ramos, Thrimoorthy Potta, David Taylor, Huang Chiao Huang, Gabriela Montanez, Ka...
https://www.sciencedirect.com/topics/materials-science/cationic-polymer
R.B. Arote, ... C.-S. Cho, in Injectable Biomaterials, 2011. Abstract: Cationic polymers that have shown significant promise as gene delivery agents are more effective than the state-of-the art, commercially available non-viral systems. Gene delivery in vivo involves interactions with the biophase (the effect site of drug) prior to reaching the target cells which complicates efforts to ...
https://www.researchgate.net/publication/237882931_Hydrophobic_modifications_of_cationic_polymers_for_gene_delivery
Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness, and proven gene delivery efficiency.
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/gene-delivery-technologies/other-cationic-polymers.html
Delivery by other Cationic Polymers ‹ Gene ... Other cationic polymers used for gene delivery include cationic peptides and their derivatives (e.g., polylysine, polyornithine), linear or branched synthetic polymers (e.g., polybrene, polyethyleneimine), polysaccharide-based delivery molecules (e.g., cyclodextrin, chitosan), natural polymers (e ...
https://pubs.rsc.org/en/content/articlelanding/2012/cs/c2cs35094g
The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientifiAuthor: Sangram Keshari Samal, Mamoni Dash, Sandra Van Vlierberghe, David L. Kaplan, Emo Chiellini, Clemens ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832905/
Oct 17, 2019 · Synthetic Polymers for Gene Delivery. The cationic molecules which are currently under development as gene delivery vehicles are organic cations, including cationic lipids, polyamine-based polymers, chitosan-based polymers, dendrimers, and polyethyleneimine (PEI) [90,91,92].Author: T. J. Thomas, Heidar-Ali Tajmir-Riahi, C. K. S. Pillai
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