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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236506/
Dec 08, 2011 · Cationic nanoparticles are shown to bind the negatively charged functional groups, such as sialic acid, found on cell surfaces and initiate translocation . Due to the highly efficient transfection property of positively charged nanoparticles, many nanoparticle-based drug and gene delivery systems are positively charged.Author: Sana Abbasi, Arghya Paul, Wei Shao, Satya Prakash
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303181/
Cationic nanoparticles can form high molecular weight aggregates with interacting proteins precluding absorption from the injection site. Lymph node retention of drug delivery devices is commonly increased by using an increased size (physical filtration) or increased hydrophobicity/receptor interactions.Author: David S. Spencer, Amey S. Puranik, Nicholas A. Peppas
https://www.sciencedirect.com/science/article/pii/S0142961211010581
Combined treatment of anticancer drugs and small interfering RNAs (siRNAs) have emerged as a new modality of anticancer therapy. Here, we describe a co-delivery system of anticancer drugs and siRNA in which anticancer drug-derived lipids form cationic nanoparticles for siRNA complexation.Author: Rae Sung Chang, Min Sung Suh, Sunil Kim, Gayong Shim, Sangbin Lee, Sung Sik Han, Kyung Eun Lee, Hyes...
https://pubs.rsc.org/en/content/articlelanding/2020/tb/c9tb02700a
Psychostimulant drugs such as amphetamine and methylated amphetamine (METH) are known to penetrate BBB. Still, little effort has been made to exploit them in nano-drug delivery, largely due to their toxicities. Herein, for the first time, we design, synthesize, and formulate three different β-amphetaminylated cationic lipid nanoparticles.
https://www.frontiersin.org/articles/10.3389/fphar.2020.00317/full
These investigations implied that cationic NPs/HCPT could be potentially applied as a promising drug delivery nanosystem. The poor solubility and permeability of most chemotherapeutic drugs lead to unsatisfactory bioavailability combined with insufficient drug concentration.
https://www.hindawi.com/journals/jnm/2013/238351/
Cationic Gelatin Nanoparticles for Drug Delivery to the Ocular Surface: In Vitro and In Vivo Evaluation Ching-Li Tseng , 1 Ko-Hua Chen , 2 , 3 , 4 Wen-Yu Su , 2 , 5 , 6 Yen-Hsien Lee , 2 , 7 Chi-Chang Wu , 1 and Fen-Huei Lin 2 , 5Author: Ching-Li Tseng, Ko-Hua Chen, Wen-Yu Su, Yen-Hsien Lee, Chi-Chang Wu, Fen-Huei Lin
https://www.nature.com/articles/nmat1737
Sep 24, 2006 · Abstract. Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors, but their comparatively low transfection efficiency has limited their applications 1. Co-delivery of drugs and DNA has been proposed to enhance gene expression or to achieve the synergistic/combined effect of drug and gene therapies 2,3,4,5,6.Author: Yong Wang, Shujun Gao, Wen-Hui Ye, Ho Sup Yoon, Yi-Yan Yang
https://www.ncbi.nlm.nih.gov/pubmed/29158673
Nov 06, 2017 · Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies.Author: Jialu Wang, Fang Zhao, Rui Liu, Jingjing Chen, Qinghua Zhang, Ruijuan Lao, Ze Wang, Xin Jin, Changxi...
https://www.sciencedirect.com/science/article/pii/S0169409X01002459
The advantages of using nanoparticles for drug delivery result from their two basic properties. First, nanoparticles, due to their small size, penetrate within even small capillaries and are taken up within cells, which allows for efficient drug accumulation at the target sites in the body [6], [7], [8].Author: Serguei V. Vinogradov, Tatiana K. Bronich, Alexander Victorovich Kabanov
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
Physical association of the drug to the nanoparticles was necessary for drug delivery to occur into the brain (Kreuter et al 2003). When nanoparticles with different surface characteristics were evaluated, neutral nanoparticles and low concentrations of anionic nanoparticles were found to have no effect on BBB integrity, whereas high concentrations of anionic nanoparticles and cationic nanoparticles …Author: Wim H De Jong, Paul Ja Borm
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