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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865214/
Cardiac Gene Therapy: Optimization of Gene Delivery ... The intent of this review is to provide a systematic classification of available in vivo gene delivery techniques, to elucidate the relative merits and deficiencies of the various methods, and to highlight the potential for incorporating effective gene therapy into the therapeutic ...Author: Michael G. Katz, JaBaris D. Swain, Jennifer D. White, David Low, Hansell Stedman, Charles R. Bridges
https://www.ncbi.nlm.nih.gov/pubmed/19947886
Cardiac gene therapy: optimization of gene delivery techniques in vivo. Katz MG(1), Swain JD, White JD, Low D, Stedman H, Bridges CR. Author information: (1)Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.Author: Michael G. Katz, JaBaris D. Swain, Jennifer D. White, David Low, Hansell Stedman, Charles R. Bridges
https://www.researchgate.net/publication/40041022_Cardiac_Gene_Therapy_Optimization_of_Gene_Delivery_Techniques_In_Vivo
76 Cardiac gene delivery techniques consider, among others, variations of heart perfusion during gene transfer, site and method of gene administration, and interventional approach like surgical ...
https://www.liebertpub.com/doi/10.1089/hum.2009.164
Mar 15, 2010 · Here we survey the available in vivo vector-mediated cardiac gene delivery methods—including transcutaneous, intravascular, intramuscular, and cardiopulmonary bypass techniques—with consideration of the relative merits and deficiencies of each. Review of available techniques suggests that an optimal method for vector-mediated gene delivery ...Author: Michael G. Katz, JaBaris D. Swain, Jennifer D. White, David Low, Hansell Stedman, Charles R. Bridges
https://www.liebertpub.com/doi/full/10.1089/hum.2009.164
In this invited review, Dr. Charles Bridges and colleagues at the University of Pennsylvania Medical Center survey current in vivo vector-mediated cardiac gene delivery methods with consideration of the relative merits and deficiencies of each delivery platform.Author: Michael G. Katz, JaBaris D. Swain, Jennifer D. White, David Low, Hansell Stedman, Charles R. Bridges
http://europepmc.org/abstract/MED/19947886
May 01, 2010 · The ideal technique is one that is efficient and practical, allowing for global cardiac gene expression, while minimizing collateral expression in other organs. Here we survey the available in vivo vector-mediated cardiac gene delivery methods--including transcutaneous, intravascular, intramuscular, and cardiopulmonary bypass techniques--with ...Author: Michael G. Katz, JaBaris D. Swain, Jennifer D. White, David Low, Hansell Stedman, Charles R. Bridges
https://academic.oup.com/cardiovascres/article/108/1/4/266142
Aug 03, 2015 · Abstract. Gene therapy is a promising modality for the treatment of inherited and acquired cardiovascular diseases. The identification of the molecular pathways involved in the pathophysiology of heart failure and other associated cardiac diseases led to encouraging preclinical gene therapy studies in small and large animal models.Author: Melvin Y. Rincon, Thierry VandenDriessche, Thierry VandenDriessche, Marinee K. Chuah, Marinee K. Chu...
http://core.ac.uk/display/8405605
Cardiac Gene Therapy: Optimization of Gene Delivery Techniques In Vivo . By Michael G. Katz, ... Here we survey the available in vivo vector-mediated cardiac gene delivery methods—including transcutaneous, intravascular, intramuscular, and cardiopulmonary bypass techniques—with consideration of the relative merits and deficiencies of each ...
https://link.springer.com/protocol/10.1007/978-1-4614-9632-8_19
Jan 23, 2014 · Gene therapy may represent a promising alternative strategy for cardiac muscle regeneration. In vivo electroporation, a physical method of gene transfer, has recently evolved as an efficient method for gene transfer. Here, we describe two protocols involving in vivo electroporation for gene transfer to the beating heart.Author: Erick L. Ayuni, Amiq Gazdhar, Marie Noelle Giraud, Alexander Kadner, Mathias Gugger, Marco Cecchini,...
https://www.ahajournals.org/doi/10.1161/JAHA.113.000119
A promising delivery technique for cardiac atrial gene therapy is epicardial painting, in which the viral vector is literally painted on to the epicardial surface suspended in a gelatinous polymer. Preclinical data show complete transmural transmission of reporter genes. 23 The down side to this method is that it currently requires an open ...Author: Julie A. Wolfram, J. Kevin Donahue
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