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https://www.ncbi.nlm.nih.gov/pubmed/17472409
Of these, only two studies in rats were able to provide results that can be seen as an indication for direct transport from the nose to the CNS. No pharmacokinetic evidence could be found to support a claim that nasal administration of drugs in humans will result in an enhanced delivery to their target sites in the brain compared with intravenous administration of the same drug under similar dosage conditions.Author: Frans W. H. M. Merkus, Mascha P. van den Berg
https://link.springer.com/article/10.2165/00126839-200708030-00001
Nov 25, 2012 · Abstract. The connection between the nasal cavity and the CNS by the olfactory neurones has been investigated extensively during the last decades with regard to its feasibility to serve as a direct drug transport route to the CSF and brain. This drug transport route has gained much interest as it may circumvent the blood-brain barrier (BBB),...Author: Frans W. H. M. Merkus, Mascha P. van den Berg
https://www.mdedge.com/neurology/article/106892/alzheimers-cognition/intranasal-drug-delivery-bypasses-blood-brain-barrier
Noninvasive intranasal stem cells bypass the blood-brain barrier to target the brain to treat Parkinson’s disease, stroke, MS, brain tumors, cerebral ischemia, Alzheimer’s and other CNS disorders.
https://www.researchgate.net/publication/276971460_Can_Nasal_Drug_Delivery_Bypass_theBlood-Brain_Barrier
In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier.
https://www.kurzweilai.net/a-drug-delivery-technique-to-bypass-the-blood-brain-barrier
Oct 26, 2015 · By functionally replacing a section of the blood-brain barrier with nasal mucosa, which is more than 1,000 times more permeable than the native barrier, surgeons could create a “screen door” to allow for drug delivery to the brain and central nervous system.
https://hms.harvard.edu/news/bypassing-blood-brain-barrier
Oct 30, 2015 · By functionally replacing a section of the blood-brain barrier with nasal mucosa, which is more than 1,000 times more permeable than the native barrier, surgeons may create a “screen door” to allow for drug delivery to the brain and central nervous system.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes.Author: Leah R Hanson, William H Frey, William H Frey
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-S3-S5
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes.Author: Leah R Hanson, William H Frey, William H Frey
https://www.sciencedaily.com/releases/2013/04/130424185207.htm
Apr 24, 2013 · Many attempts have been made to deliver drugs across the blood-brain barrier using methods such as osmotic disruption and implantation of catheters into the brain, however these methods are temporary and prone to infection and dislodgement. "As an endoscopic skull base surgeon,...
https://www.researchgate.net/publication/234044763_Nose_to_Brain_Targeted_Drug_Delivery_bypassing_the_Blood-Brain_Barrier_An_overview
It is thought to do so through olfactory route of drug transport which bypass the blood-brain barrier (BBB) and allow the direct transport of drug from the nose to the brain.
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