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https://www.sciencedirect.com/science/article/abs/pii/S0168365919300343
The tumor microenvironment(TME)-responsive intelligent drug delivery systems are still the hot research topics in delivering chemotherapeutic drugs. Camptothecin (CPT) possesses very strong antitumor activities, but its clinical application is hindered by its poor water-solubility and serious toxic side effects.Author: Ying Qu, Bingyang Chu, Xiawei Wei, Minyi Lei, Danrong Hu, Ruoyu Zha, Lin Zhong, Mengyao Wang, Fangfa...
https://www.sciencedirect.com/topics/medicine-and-dentistry/camptothecin
Camptothecin. Camptothecin is a naturally occurring alkaloid derived from the plant Camptotheca acuminata that was identified in an anticancer drug discovery screen in the 1960s.67 Camptothecin forms a stable ternary complex, preventing normal DNA re-ligation, and causes the complex to collide with the replication fork, leading to a DNA double-strand break and cytotoxicity.68
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299461/
Nov 22, 2011 · Therefore there is a need for development of new chemotherapeutic drugs and drug delivery systems for the treatment of colon cancer. Camptothecin (CPT), a modified monoterpene indole alkaloid, produced by Camptotheca acuminate, was first isolated by Wall and co-workers in 1966 .Author: Naveen K. Thakral, Alok R. Ray, Daniel Bar-Shalom, André Huss Eriksson, Dipak K. Majumdar
https://www.ncbi.nlm.nih.gov/pubmed/29630986
May 28, 2018 · In order to improve the efficiency of drug release, fusogenic nanodroplets were designed to go from nano to micron size upon uptake by ADSCs for reducing ADV threshold. The purpose of our study was to demonstrate the utility of camptothecin-loaded fusogenic nanodroplets (CPT-FNDs) as ultrasound theranostic agents in an ADSCs delivery system.Author: Yi-Ju Ho, Yu-Jung Chiang, Shih-Tsung Kang, Ching-Hsiang Fan, Chih-Kuang Yeh
https://iopscience.iop.org/article/10.1088/1361-6528/ab529b/pdf
Lytic peptide-grafted beta-cyclodextrin polymer based nano-scaled drug delivery system with enhanced camptothecin anti-cancer efficacy Honglei Zhan1, He Zhao1, Nazim Muhammad1, Tongtong Li1, Yujia Liu1 and Jihui Wang1,2,3 1Department of Biotechnology, School of Bioengineering, Dalian Polytechnic University, Dalian, 116034, Liaoning Province, People’s Republic of ChinaAuthor: Honglei Zhan, He Zhao, Nazim Muhammad, Tongtong Li, Yujia Liu, Jihui Wang, Jihui Wang
https://cancer.osu.edu/news/rna-nanoparticles-may-improve-the-solubility-delivery-and-safety-of-cancer-chemotherapy#!
Two studies led by researchers at the OSUCCC – James suggest that RNA nanoparticles may vastly improve the solubility, delivery and safety of two
https://onlinelibrary.wiley.com/doi/pdf/10.1002/asia.201301030
Oct 17, 2013 · Preparation of a Camptothecin Prodrug with Glutathione‐Responsive Disulfide Linker for Anticancer Drug Delivery. Dr. Zhigang Xu. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (P.R. China), Fax: (+86) 931‐8912582 ... We present here a novel camptothecin ...Author: Zhigang Xu, Zhigang Xu, Dongdong Wang, Shuang Xu, Xiaoyan Liu, Xiaoyu Zhang, Haixia Zhang
https://www.dovepress.com/sustained-delivery-of-a-camptothecin-prodrug-cz48-by-nanosuspensions-w-peer-reviewed-fulltext-article-IJN
The formulation offers potential merits as a preferred candidate for clinical trials with the prolonged CPT exposure, which is known to correlate with the clinical efficacy.Keywords: sustained drug delivery, CZ48, camptothecin, nanosuspension, anticancerAuthor: Dong Dong, Cheng-Hui Hsiao, Beppino C Giovanella, Yifei Wang, Diana Sl Chow, Zhijie Li
https://pubs.acs.org/doi/abs/10.1021/jm9600555
This article is cited by 83 publications. Peichen Pan, Jiean Chen, Xijian Li, Miyang Li, Huidong Yu, Jean J. Zhao, Jing Ni, Xuwen Wang, Huiyong Sun, Sheng Tian, Feng Zhu, Feng Liu, Yong Huang, Tingjun Hou. Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo.Author: Richard B. Greenwald, Annapurna Pendri, Charles Conover, Carl Gilbert, Ross Yang, Jing Xia
https://www.researchgate.net/publication/281282862_Advantage_and_Disadvantage_in_Drug_Delivery_Systems
Apr 10, 2011 · Nanotechnology is a multidisciplinary scientific field. Nanotechnology advances in drug delivery deal with the development of synthetic nanometer sized targeted delivery systems for therapeutic ...
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