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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881614/
Mar 04, 2016 · Calcium phosphate (CaP) was developed for the delivery of DNA nearly 40 years ago [42, 43] and siRNA in recent years [44]. As a similar element of bone and teeth, CaP shows negligible cytotoxicity for siRNA delivery due to its inherent biocompatibility and biodegradability [45, 46].Author: Xiaochun Xu, Zehao Li, Xueqin Zhao, Lawrence Keen, Xiangdong Kong
https://www.mdpi.com/2079-4991/10/1/146/htm
The potential of a triple shell calcium phosphate/siRNA/calcium phosphate/PEI for siRNA delivery for knocking down tumor necrosis factor alpha (TNF-α) in the treatment of tumor cells was investigated by Neuhaus et al. . They successfully reduced gene expression to 18% of the original value, while cell viability remained ≥70% .Author: Tanya J. Levingstone, Simona Herbaj, John Redmond, Helen O. McCarthy, Nicholas J. Dunne
https://pubs.rsc.org/en/content/articlelanding/2018/bm/c8bm00575c
Calcium phosphate (CaP) nanoparticles present a class of promising nonviral gene delivery carriers due to their easy-preparation procedure, low toxicity and high transfection efficiency. PEGylated polyanion block copolymer was widely used to control the CaP crystal growth during CaP co-precipitation with therapeutic genes.Author: Quan Zhou, Yue Wang, Jiajia Xiang, Ying Piao, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Youqing Shen
https://pubs.rsc.org/en/content/articlelanding/2016/nr/c6nr04034a#!
In this study, hyaluronan (HA)-functionalized calcium phosphate nanoparticles (CaP-AHA/siRNA NPs) were developed for an injectable and targetable delivery of siRNA, which were prepared by coating the alendronate-hyaluronan graft polymer (AHA) around the surface of …
https://www.frontiersin.org/articles/10.3389/fchem.2020.00161/full
Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor.
https://www.sciencedirect.com/science/article/pii/S0168365911009928
Calcium phosphate (CaP) nanoparticles (NP) with an asymmetric lipid bilayer coating have been designed for targeted delivery of siRNA to the tumor. An anionic lipid, dioleoylphosphatydic acid (DOPA), was employed as the inner leaflet lipid to coat the nano-size CaP cores, which entrap the siRNA, such that the coated cores were soluble in organic solvent.Author: Jun Li, Yang Yang, Leaf Huang
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