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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469233/
Sep 06, 2012 · Introduction. The purpose of this manuscript is to provide a brief, up-to-date (as of April 2012) review on calcitonin with special emphasis on its clinical efficacy in the management of osteoporosis, arthritis, and pain and on the trials and tribulations of developing an oral formulation.
https://emisphere.com/improved-oral-delivery-eligen/
PTH-1-34 is an injectable peptide for the treatment of women with postmenopausal osteoporosis. A combination of human PTH-1-34 and the absorption enhancer 5-CNAC using Emisphere’s proprietary Eligen ® Technology has been investigated in a Phase I study to assess the bioavailability profile of increasing doses of PTH-1-34 administered orally. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041962/
Sep 29, 2010 · For both growth hormone and salmon calcitonin, the primary administration option is injection therapy. An improved delivery option would be the oral route, an option that eliminates the fear 17 and pain 18 associated with injection therapy and improves the quality of lifeAuthor: Daniel A. Carr, Marta Gómez-Burgaz, Mathilde C. Boudes, Nicholas A. Peppas
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ondrugdelivery.com/technologies-clinical-studies-oral-delivery-calcitonin/
Nozer Mehta, James P Gilligan and William Stern summarise the different technologies that have been in development for oral delivery of peptides through the gastro-intestinal mucosal surfaces via the transcellular or the paracellular pathways and describe the results of several long-term clinical studies on the oral delivery of salmon calcitonin.
https://www.researchgate.net/publication/223600065_Oral_delivery_of_salmon_calcitonin
Calcitonin plays a crucial role in both calcium homeostasis and bone remodeling. Establishing an oral delivery system for CT is of great importance since CT is currently administered only ...
https://www.sciencedirect.com/science/article/pii/S0169409X00000636
Aug 31, 2000 · Calcitonin is an excellent candidate for the development of alternate delivery routes due to its size and wide therapeutic index with a preference towards the oral delivery route. One requirement for its oral delivery is intestinal stabilization since sCT is a …Author: Yong-Hee Lee, Patrick J Sinko
https://www.ondrugdelivery.com/review-oral-peptide-delivery/
Oral formulations of salmon calcitonin using Peptelligence ® technology completed a randomised, double-blind, doubledummy, active- and placebo-controlled multiple-dose Phase III clinical trial in 565 post-menopausal osteoporotic patients. 13 It was found that the oral calcitonin formulation achieved improved efficacy versus the marketed nasal ...
https://ttu-ir.tdl.org/handle/2346/14705
Oral delivery of proteins may be enhanced by the use of enzyme inhibitors and absorption enhancers. In the present study, ovomucoids has been investigated as enzyme inhibitor in the oral delivery of salmon calcitonin. Glycyrrhetinic acid was employed as the absorption enhancer. Enzymatic degradation studies revealed that salmon calcitonin is ...Author: Rakhi Bharat Shah
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