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https://pubmed.ncbi.nlm.nih.gov/29526138/#:~:text=In%20conclusion%2C%20it%20seems%20that%2012%20hours%20interval,be%20performed%20on%20this%20issue%20and%20various%20morbidities.
https://clinicaltrials.gov/ct2/show/NCT00453141
Betamethasone makes breathing easier for them, also decreases the chance of them bleeding in the head and makes their chances of survival better. This medicine is used routinely in pregnancy but the best timing between doses in not well established. The 'standard' dosing schedule involves giving 2 injections of 12mg of the medicine 24 hours apart.
https://pubmed.ncbi.nlm.nih.gov/29526138/
In conclusion, it seems that 12 hours interval betamethasone therapy may be considered as an alternative treatment in the case of preterm labour for acceleration of lung maturity; however, it is suggested that more studies should be performed on this issue and various morbidities.
https://www.contemporaryobgyn.net/view/betamethasone-dosing-12-hours-beneficial-preterm-birth
Betamethasone Dosing at 12 Hours is Beneficial in Preterm Birth. April 10, 2012. Heidi Anne Duerr, MPH. Research has shown that glucocorticoid administration has a significant beneficial effect for preterm births, as it decreases the incidence of respiratory distress syndrome in infants delivered between 24 weeks and 34 weeks gestation, reduces the incidence of intraventricular …
https://pubmed.ncbi.nlm.nih.gov/16801314/
Dosing betamethasone in 12-hour intervals may result in similar neonatal outcomes compared to the standard 24-hour regimen when delivery occurs within 48 hours of therapy initiation. The first 48 hours: Comparing 12-hour and 24-hour betamethasone dosing when preterm deliveries occur rapidly
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