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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075473/
The aim of this study was colon targeted delivery of budesonide to deliver the major part of the drug to the colon using physical approach of solid dispersion technique instead of chemical prodrug preparation. This approach can reduce side effects of the drug and increase its effectiveness in the site of action.Author: Jaleh Varshosaz, Fatemeh Ahmadi, Jaber Emami, Naser Tavakoli, Mohsen Minaiyan, Parvin Mahzouni, Fari...
https://www.drugs.com/pro/budesonide-capsule.html
Jun 29, 2018 · Budesonide had a plasma clearance, 0.9 L/min to 1.8 L/min in healthy adults. Mean plasma clearance after intravenous administration of budesonide in patients with Crohn’s disease was 1.0 L/min. These plasma clearance values approached the estimated liver blood flow, and, accordingly, suggest that budesonide is a high hepatic clearance drug.6.9/10
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · a. pH Sensitive Polymer Coated Drug Delivery to the Colon . In the stomach, pH ranges between 1 and 2 during fasting but increases after eating.18 The pH is about 6.5 in the proximal small intestine, and about 7.5 in the distal small intestine.19 From the ileum to the colon, pH declines significantly. It is about 6.4 in the cecum.Author: Anil K. Philip, Betty Philip
https://www.sciencedirect.com/science/article/pii/S0974694313001618
Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn's disease, amebiasis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs.Author: Raosaheb S. Shendge, Fahim J. Sayyad
https://www.researchgate.net/publication/244994822_Colon_targeted_drug_delivery_systems-A_review
Day by day there are new developments in field of colon specific drug delivery system. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the ...
https://link.springer.com/article/10.1208%2Fs12249-015-0350-9
Jun 13, 2015 · Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions.Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
https://www.hindawi.com/journals/jdd/2012/905191/
Budesonide, a potent glucocorticoid, is used for the treatment of inflammatory bowel diseases. Current available oral formulations of budesonide have low efficacy against ulcerative colitis because of the premature drug release in the upper part of the gastrointestinal tract. In this paper a pH- and time-controlled colon-targeted pellet-based tablet of budesonide was established. Pellet cores ...Author: Jaleh Varshosaz, Jaber Emami, Naser Tavakoli, Mohsen Minaiyan, Nakisa Rahmani, Farid Dorkoosh
https://www.dovepress.com/colon-targeted-delivery-of-budesonide-using-dual-ph--and-time-dependen-peer-reviewed-fulltext-article-DDDT
Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy Muhammad Naeem,1 Moonjeong Choi,1 Jiafu Cao,1 Yujeong Lee,1 Muhammad Ikram,2 Sik Yoon,2 Jaewon Lee,1 Hyung Ryong Moon,1 Min-Soo Kim,1 Yunjin Jung,1 Jin-Wook Yoo11College of Pharmacy, Pusan National University, Busan, 2Pusan National University School of Medicine, …
https://www.researchgate.net/publication/40694388_Colon_Delivery_of_Budesonide_Evaluation_of_Chitosan-Chondroitin_Sulfate_Interpolymer_Complex
Colon Delivery of Budesonide: Evaluation of Chitosan-Chondroitin Sulfate Interpolymer Complex ... ABSTRACT Colon-specific drug delivery has found important applications in the wide array of ...
https://www.mdpi.com/1422-0067/16/2/2693/htm
A novel budesonide (BUD) colon delivery release system was developed by using a natural polysaccharide, guar gum. The rigidity of the microspheres was induced by a chemical cross-linking method utilizing glutaraldehyde as the cross-linker. The mean particle size of the microspheres prepared was found to be 15.21 ± 1.32 µm. The drug loading and entrapment efficiency of the formulation were …Author: Ye Liu, Hong Zhou
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